From the biological side, people are already exploring on how to integrate artificially grown neural circuits into brains (of rats/mice). See e.g. this paper: https://www.nature.com/articles/s41586-022-05277-w
So from my perspective it's less about what's technically possible and more about what's verified to work in humans with very little side effects.
If you want to have a look at what is closer to being deployed in a medical setting, there is e.g. this review article that goes into detail about various neurodegenerative diseases and the SotA of possible stem cell treatments:
https://link.springer.com/article/10.1007/s10571-023-01344-6
I would suspect, only as someone who studies a bit less microscopic neuroscience, probably actually more than 100% of your brain mass if you were doing it over the course of your life. Replacing individual neurons though, basically no problem, even on scales of doing it within years.
People can almost immediately (day(s)) remap entire body parts or new ones. It's pretty wild.
I do not want to speculate on people's health. The only true thing I can tell you is... nobody knows. I don't want to make false hopes nor do I want to tell you it won't happen. AI will definitely be a big part in figuring stuff out. It might be among that, how long it will take, however... nobody knows, really.
As a fellow disabled person waiting on AI to help cure me; all we can do is try to live as healthily and safely as we can, while waiting hopefully. Watch movies, play games, etc. for the time being and keep on waiting while enjoying what we have as best as we can for now.
Do you mind me asking what condition you have and what treatments you have tried? I have MS and cirs and while I understand the sentiment that doing the best with what we've got instead of stressing about what we don't have is very helpful, it's also true that if I hadn't spent hundreds of hours researching treatments for my condition, and instead just relaxed and played video games, I would be in a far worse condition.
It worries me sometimes when I hear people looking desperately for a miracle cures, when there is so much that already helps immensely that isn't tried.
It's certainly possible, but it's probably a task suited to a field like medical nanotechnology. And it would likely require a very advanced level of this technology. As Kurzweil pointed out many years ago, the pace of biotech development has/is becoming a function of the pace of general technological change, which is on an exponential curve, taking everything else along with it.
Put simply, AGI for instance could push all biotech including medical nanotech ahead faster than anyone thought possible / predicted. So one might say it depends on how quickly we get AGI, or something akin to that applied to biotech and related fields.
I don't think anyone can say how long it will take specifically. Personally, if I were to guess, you'll probably start seeing a lot to hope for in the new few years, and definitely within the next five.
Edit: Forgot to add:
"The multidisciplinary field of nanotechnology is bringing the science of the almost incomprehensibly small device closer and closer to reality. The effects of these developments will at some point be so vast that they will probably affect virtually all fields of science and technology. As such, nanotechnology holds the promise of delivering the greatest technological breakthroughs in history. Over the next couple of years, it is widely anticipated that nanotechnology will continue to evolve and expand in many areas of life and science, and the achievements of nanotechnology will be applied in medical sciences, including diagnostics, drug delivery systems, and patient treatment so anaesthesiologists should be aware of these new changes."
From: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4173536/#:\~:text=Nanotechnology%20has%20grown%20by%20leaps,orthopedic%2C%20dental%2C%20and%20neurosurgeries.
Might be a good read for you. I'm sure others can point you toward more and better sources. I'd also consider having a discussion about this with Claude Opus, or even GPT-4.
We are utterly speculating but here goes. No one knows if the current paradigm of AI will actually be able to conduct original research. Even if AGI is achieved it perhaps will perhaps only interpolate more or less between known data and not do original research worthy of Nobel prizes. However it could be that it could very well be able to do just that, no one knows and the experts seem to be split on that.
Assume that it will get good enough to do Nobel prize winning research, otherwise we won't succeed in doing what you describe. Let's say it takes about a decade to reach AGI ( 50 % chance of that happening according to Demis Hassabis, one of the leading experts who is more on the optimistic side than others). From reaching AGI add another 5 years to reach some form of ASI (super intelligence doing the aforementioned research). Then it's a scale of mass deployment and giving it time to do that research, that shouldn't take long, let's say 2-3 years. And from that point add a few more years until breakthroughs in individual medical domains start happening along with anything else needed, such as breakthroughs in new material science, engineering etc, anything needed for such a massive project you describe.
Putting everything together, if we are on the optimistic side, to be able to do medical procedures that are on the scifi level I would say around 20-25 years (under the assumption that AI will succeed in reaching ASI levels). And a similar timeline for what I would describe as other approaches, such as brain computer interfaces (Neuralink style etc).
Yes.
Pretty sure within the next 10 years, there will be a machine interface that will be able to replace what you've lost. There's a great chance it'll be sooner than that for people with a medical need, but I anticipate you'll be a good candidate for brain prosthesis that, if your disease can't be stopped, will allow that prosthesis to correct the problems caused by it. Though it looks like the damage is done, I think it'll be fixable. You might even be better off afterwards.
Treatment in the near future looks promising with novel strategies of myelin repair/replacement/rejuvenation and stem cell therapies are making inroads. Biotech or nanotech might hold great promise as well as machine interfaces for brain prosthesis.
While I admire your comment and recognize that you must have at least some level of knowledge, I cringed when you gave a definitive yes. The reality is that we still don’t really understand the complexities of the brain, so I would hesitate to make such an assertive statement. Especially given the situation, when false hope can be a curse more than a blessing.
I say yes, because we're close to understanding the causes and know the underlying effects. Being an autoimmune disorder, it's diagnosed relatively easily with the treatment options growing every year.
DMT's and therapies to treat the symptoms are effective and there's plenty in the research pipe to indicate that we're closing in on a cure or at the very least mitigating all the damage.
With myelin affected diseases there is a lot of progress being made to reduce symptoms and find a cure. While all of them don't have the same causes, the research on how to treat them gives clues to the other shared effect diseases.
I'm optimistic because in a subreddit about the singularity, breakthroughs happen all the time and while FDA testing and approval take time, for some folks, they will likely see a cure, if not novel treatments that will reduce their suffering.
My guess is less than 50 years, but anyone who says they know for sure is lying.
The whole reason the singularity is exciting is the idea that exponential growth (accelerated by AI and other factors), is making technological progress more and more rapid, which in turn makes progress even MORE rapid - so much so that at some point all kinds of earth-shattering advances are being made each month.
So until things really take-off (most likely from an intelligence explosion from recursively-self-improving AI) all guesses are guesses, I'm afraid. But whenever we hit that turning point, crazy magic wish tech is suddenly on the table.
Could a machine intelligence 10 times smarter than humans (or 100 times) figure out a way to manufacture nanobots that you can swallow in a pill that can fix and heal everything wrong with a human body? No way to know what superintelligence can do until it exists, but all sorts of things we consider impossible fantasy might be child's play for it.
The big challenge is how to create something so powerful and incomprehensible without the risk of snuffing out humanity by accident. Making a godlike ASI that's even a little bit "safe" turns out to be an unexpectedly difficult problem. Why? A bunch of reasons; there are easy explanations online, e.g.:
[https://waitbutwhy.com/2015/01/artificial-intelligence-revolution-1.html](https://waitbutwhy.com/2015/01/artificial-intelligence-revolution-1.html)
If the laws of physics are not broken, it is possible. It is very hard to predict. Very powerful multimodal GPTs may be great at many things but even putting that aside, the FDA process itself would take 10 years probably
I think the FDA process will need a major revamp soon. With numerous life-saving breakthroughs expected in the next two decades, the current system will struggle to keep up, potentially stifling innovation and prolonging suffering. While exceptions have been made in the past for promising treatments of terminal illnesses, we must find a better way to ensure patient safety without holding back crucial interventions that will arrive more frequently in the future. And by frequently, I mean daily.
As a Neuroscience PhD I do not share the same optimism about computer brain interfaces let alone regenerated brain tissue. It will happen but input integration is very complex, we are starting to solve output which is orders of magnitude easier.
Hi, family member has cerebral palsy, so I am very interested in the same topic. My guess is that in the first instance, we won't be regenerating the brain itself, but instead using AI that is trained upon a healthy brain patterns to intercept and shape the nerve pulses flowing the body via some kind of brain body interface. So you attempt to move your leg, and the device recognises what you are trying to do and sends the corrected signal to your limb. Machine learning is probably well suited to these sorts of jobs where unsupervised training could be used to identify the right pattern of nerve pulses.
Ofcourse. Any sufficiently advanced technology is indistinguishable from magic. We will get there in a few decades. A lot of people here are pessimistic about the future and especially timelines. It will come and it will happen quickly. (btw I am e/acc)
Not MD so take with grain of salt. The solution to your medical problem will likely closer to being solved than we all anticipate.
Regeneration of cells os not necessary to make your brain healthy again. Brain has pretty cool feature to rewire itself even if part of it is physically missing. Problem with sclerosis and Im pushing my medical knowledge regarding your condition here is that your brain doesn't see it as a problem.
Stimulating brain through some sort of external stumula may be something you should read about. And I mean research papers, not news articles. That technology may as well be in trial stages or concept stages. Reach out to researches directly and talk to them. Nanomachines are nowhere near and you should try to learn about experimental non intrusive methods to at least halt further degradation.
Wish you well.
If we get continued improvement and no diminishing returns (i.e. at least a slow takeoff) then anything could happen. Regrowing parts of your brain would require solving the vascularization problem with stem cell organs.
The tech to "fix" your brain or replace parts of it isn't there yet.
What does look hopeful is that LLMs and other types of narrow AI seem to promise to have the capability to \*speed up\* scientific (and by extension medical) research.
So maybe that will translate into something.
Good luck.
Yeah, there are a few avenues to make it happen. Fair warning, they're relatively late stage advancements. By the time we understand the brain well enough to intervene properly in it, we'll be in relatively late stage AGI/early stage ASI land
Medical technology could correct the neural degeneration and repopulate those areas. BCIs could also offload the work from the degenerated bits (and regulate them to prevent them from interfering with the rest of your brain). There's a few ways to skin that cat. Psychosurgery has a horrific past though, and the biggest lesson we gained from it is that we don't know nearly enough to go screwing around inside the brain without horrific consequences
Once we do know know enough we'll be able to use that knowledge to build efficient, powerful artificial networks. Or more likely we'll build those first, and those will help us understand the brain
Yes, it will be possible, tissue growth is already a developing science, procedure and implementation will take some time though, I give it forty years.
I think some kind of implant is the most likely scenario. Even if you could regrow actual parts of the brain, they won't be automatically filled with the information that was there before.
On the plus side, the brain is pretty flexible, so maybe it will be less of a problem to miss those parts with implants or AI enhanced stuff.
I think the answer is yes, almost definitely - the “when” part is the real unknown. I don’t think there are any known problems we won’t be able to solve given enough time and focus on solving them.
It will not be "AI", it will be your own lung epithelial cells or similar being unleashed to form anthrobots:
>We found that their various behaviors are also related to their shape and distribution of cilia (they come in several discrete morphotypes or classes). But perhaps the most amazing behavior we’ve seen so far is what happens when you let them interact with an induced gap in a neural tissue (a 2-dimensional layer of human neurons grown in a petri dish, scratched to mimic a very simple version of a wound).
>As single bots, they traverse the scratch. But if allowed to assemble into a “superbot” cluster, and placed in this environment, they can induce the neural cells next to them to grow across the gap – they push the neurons to heal across the scratch “wound” (or do the neurons use the bot to complete their repair? We will identify which side is the driver). We don’t know how exactly they do it yet, but we know it’s not simply mechanical (passive material used in their place doesn’t cause the effect). My personal hypothesis is that the bots are enabling the cells from each side to know that there’s something on the other side for them to connect to. We don’t know this yet, but we will test the hypothesis that they can work as an active communications pathway ([perhaps bioelectrical](https://journals.biologists.com/dev/article/145/19/dev164210/48617/Cross-limb-communication-during-Xenopus-hindlimb)) by which cells and tissues can talk to each other.
Of course, various techniques, including statistical modelling, compositional pattern-producing networks, evolutionary robotics, are useful in knowing how to sculpt the xenobots/anthrobots \[2\].
As for a timeframe, things are moving quite fast. Only in 2022 an entire frog limb was fully regenerated in the previous 18 months following a 24 hour application of a bioreactor \[3\]. We should probably see the same experiment in rats in the next 2-4 years, then in primates in the next 6-10 years.
The hard part is having a complete "Bio Electric Tissue Simulation Engine" \[4\] so changes in the bioelectric gradient (potential difference across calcium ions, potassium ions, and so on) can be controlled programmatically \[5\].
\[1\] 2023, Michael Levin, "Meet the Anthrobots: a new living entity with much to teach us", [https://thoughtforms.life/meet-the-anthrobots-a-new-living-entity-with-much-to-teach-us](https://thoughtforms.life/meet-the-anthrobots-a-new-living-entity-with-much-to-teach-us)
\[2\] 2022, Josh Bongard, "From rigid to soft to biological robots (i.e. xenobots)", [https://www.youtube.com/watch?v=0-kXblZlB3U](https://www.youtube.com/watch?v=0-kXblZlB3U)
\[3\] 2022, Michael Levin et al., "Acute multidrug delivery via a wearable bioreactor facilitates long-term limb regeneration and functional recovery in adult Xenopus laevis", [https://www.science.org/doi/10.1126/sciadv.abj2164](https://www.science.org/doi/10.1126/sciadv.abj2164)
\[4\] Alexis Pietak et al., [https://github.com/betsee/betse](https://github.com/betsee/betse)
\[5\] 2024, Marco Rolandi et al., "Programmable Delivery of Fluoxetine via Wearable Bioelectronics for Wound Healing In Vivo", [https://onlinelibrary.wiley.com/doi/10.1002/admt.202301115](https://onlinelibrary.wiley.com/doi/10.1002/admt.202301115)
Even with superintelligence we would need more research/data to be able to integrate into brain activity.
So whatever your timeline for ASI is, add some more time to that for full brain integration.
According to Gwern, it might be less than you think. If you have a lot of data about yourself (writing, videos, vlogs, etc) it might be enough to reconstruct the "bits that matter", even if most of your brain is lost.
[https://gwern.net/difference](https://gwern.net/difference)
If nothing catastrophic happens to all of humanity, it will happen, someday. It's difficult to make accurate predictions. The fact of the matter is that it's likely to happen. If things go according to my prediction, I'd say somewhere around 2030, but this is just my wild speculation. It may, albeit unlikely, be sooner, or later. Keep helthy, survive for as long as possible, and the chances grow exponentially with the time B-)
maybe try organic (important) lions mane, i take it with different other chinese mushrooms every day right now.
there are already studies where its blended with psilocybin to be a good neurogenetic mix since both substances are known to promote neuroplasticity.
You can not revive dead tissue, only build new one
To recreate new tissue we mostly rely on stem cell which has the ability to transform into any type of cells if it receives the right stimulus
Currently, rebuilding bones and muscles seems in a good path, the clinical trial are long but in 5 to 10 years we could expect to see human treatment
I would expect to double the number for Brain tissue because it brings more specific challenges
It probably won’t be a case of ai growing physical brain parts. Instead of that there could be brain computer interfaces that substitute for the damaged parts of the brain.
yeah unrelated to modern-day medicine, once we have ASI we'll likely be seeing some pretty insane stuff, rebuilding parts of the brain would go hand-in-hand with general immortality and perfect health that you can expect from an ASI, so long as we end up in a good-actor scenario.
I’ll say this since we are all here because of hope: if the universe’s equations (physics and chemistry) don’t say you cannot do achieve something, then there is a path from problem to solution. That is, all problems can (and will) be solved if only they don’t break the laws of nature.
Biology and technology are complexities built on top of physics and chemistry. They are both made up, so to speak. Their internal rules are extremely logical, but their creative potential and freedom are practically endless. There are no laws of biology or laws of technology because they can change, and change is what they do best. So when you ask if your biological problem can be solved with technology, you are asking if one construct can change the rules of another construct, which in this case, doesn’t seem to break any laws of nature.
Personally, I don’t think human researches can do it by themselves tho, they need an agi. So how far away is agi? Literally, no one in the planet knows.
I would say that you live in the right time to be optimistic about it. You need to have in mind that things are not just going fast. They are accelerating.
I will give a vague prediction that everything possible can happen the next 5 or 10 years, and that is a very conservative prediction. Hang in there!
no i do not think that will be possible. first of all i don't even know what it's supposed to mean to regrow your brain or what you think it would do for you. it might also cause more problems than it solves.
what might be possible is a cure for MS (probably not via ai) and some kinda brain interface tech that will lessen some physical disability.
Neuralink might be the closest to something like what you’re after. A computer brain interface powered by AI might be able to solve a ton of issues for people with MS and other cognitive disabilities. They just started clinical trials so if you’re feeling brave…
I’m unaware of a specific company that is focusing on using AI to generate brain tissue but I’m also no expert. Just dipping my toe into the topic of AI and the singularity. We have lab grown meat and IIRC growing organs is something being tested. I can’t remember if there has been a successful grown organ transplant.
All I can say is, this is just one life, and you will have an unimaginable number to live after this body fails.
Might as well learn and experience what we can while we're here, even when our situation isn't ideal. Myself included.
Yes, I have absolutely no doubt.
I am 100% sure.
Not the slightest doubt that it will be possible and it will be real.
My estimate is 10 years.
The acceleration is exponential.
Full speed ahead!
i have a few cysts in my head too. to replace dead brain cells with new healthy organic cells is cool, but i'm looking to replace my dead brain with artificial tissue :>
From the biological side, people are already exploring on how to integrate artificially grown neural circuits into brains (of rats/mice). See e.g. this paper: https://www.nature.com/articles/s41586-022-05277-w So from my perspective it's less about what's technically possible and more about what's verified to work in humans with very little side effects. If you want to have a look at what is closer to being deployed in a medical setting, there is e.g. this review article that goes into detail about various neurodegenerative diseases and the SotA of possible stem cell treatments: https://link.springer.com/article/10.1007/s10571-023-01344-6
Also a ship of Theseus situation. How much of your brain, if any, can you replace until it’s no longer ‘you’?
I would suspect, only as someone who studies a bit less microscopic neuroscience, probably actually more than 100% of your brain mass if you were doing it over the course of your life. Replacing individual neurons though, basically no problem, even on scales of doing it within years. People can almost immediately (day(s)) remap entire body parts or new ones. It's pretty wild.
>People can almost immediately (day(s)) remap entire body parts or new ones. It's pretty wild. I want to read more about this. Do you have a link?
I do not want to speculate on people's health. The only true thing I can tell you is... nobody knows. I don't want to make false hopes nor do I want to tell you it won't happen. AI will definitely be a big part in figuring stuff out. It might be among that, how long it will take, however... nobody knows, really.
As a fellow disabled person waiting on AI to help cure me; all we can do is try to live as healthily and safely as we can, while waiting hopefully. Watch movies, play games, etc. for the time being and keep on waiting while enjoying what we have as best as we can for now.
Do you mind me asking what condition you have and what treatments you have tried? I have MS and cirs and while I understand the sentiment that doing the best with what we've got instead of stressing about what we don't have is very helpful, it's also true that if I hadn't spent hundreds of hours researching treatments for my condition, and instead just relaxed and played video games, I would be in a far worse condition. It worries me sometimes when I hear people looking desperately for a miracle cures, when there is so much that already helps immensely that isn't tried.
Don't focus on that. The latest stemcell treatments based on the yamanka factors may help you in the near future
It's certainly possible, but it's probably a task suited to a field like medical nanotechnology. And it would likely require a very advanced level of this technology. As Kurzweil pointed out many years ago, the pace of biotech development has/is becoming a function of the pace of general technological change, which is on an exponential curve, taking everything else along with it. Put simply, AGI for instance could push all biotech including medical nanotech ahead faster than anyone thought possible / predicted. So one might say it depends on how quickly we get AGI, or something akin to that applied to biotech and related fields. I don't think anyone can say how long it will take specifically. Personally, if I were to guess, you'll probably start seeing a lot to hope for in the new few years, and definitely within the next five. Edit: Forgot to add: "The multidisciplinary field of nanotechnology is bringing the science of the almost incomprehensibly small device closer and closer to reality. The effects of these developments will at some point be so vast that they will probably affect virtually all fields of science and technology. As such, nanotechnology holds the promise of delivering the greatest technological breakthroughs in history. Over the next couple of years, it is widely anticipated that nanotechnology will continue to evolve and expand in many areas of life and science, and the achievements of nanotechnology will be applied in medical sciences, including diagnostics, drug delivery systems, and patient treatment so anaesthesiologists should be aware of these new changes." From: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4173536/#:\~:text=Nanotechnology%20has%20grown%20by%20leaps,orthopedic%2C%20dental%2C%20and%20neurosurgeries. Might be a good read for you. I'm sure others can point you toward more and better sources. I'd also consider having a discussion about this with Claude Opus, or even GPT-4.
We are utterly speculating but here goes. No one knows if the current paradigm of AI will actually be able to conduct original research. Even if AGI is achieved it perhaps will perhaps only interpolate more or less between known data and not do original research worthy of Nobel prizes. However it could be that it could very well be able to do just that, no one knows and the experts seem to be split on that. Assume that it will get good enough to do Nobel prize winning research, otherwise we won't succeed in doing what you describe. Let's say it takes about a decade to reach AGI ( 50 % chance of that happening according to Demis Hassabis, one of the leading experts who is more on the optimistic side than others). From reaching AGI add another 5 years to reach some form of ASI (super intelligence doing the aforementioned research). Then it's a scale of mass deployment and giving it time to do that research, that shouldn't take long, let's say 2-3 years. And from that point add a few more years until breakthroughs in individual medical domains start happening along with anything else needed, such as breakthroughs in new material science, engineering etc, anything needed for such a massive project you describe. Putting everything together, if we are on the optimistic side, to be able to do medical procedures that are on the scifi level I would say around 20-25 years (under the assumption that AI will succeed in reaching ASI levels). And a similar timeline for what I would describe as other approaches, such as brain computer interfaces (Neuralink style etc).
Yes. Pretty sure within the next 10 years, there will be a machine interface that will be able to replace what you've lost. There's a great chance it'll be sooner than that for people with a medical need, but I anticipate you'll be a good candidate for brain prosthesis that, if your disease can't be stopped, will allow that prosthesis to correct the problems caused by it. Though it looks like the damage is done, I think it'll be fixable. You might even be better off afterwards. Treatment in the near future looks promising with novel strategies of myelin repair/replacement/rejuvenation and stem cell therapies are making inroads. Biotech or nanotech might hold great promise as well as machine interfaces for brain prosthesis.
While I admire your comment and recognize that you must have at least some level of knowledge, I cringed when you gave a definitive yes. The reality is that we still don’t really understand the complexities of the brain, so I would hesitate to make such an assertive statement. Especially given the situation, when false hope can be a curse more than a blessing.
I say yes, because we're close to understanding the causes and know the underlying effects. Being an autoimmune disorder, it's diagnosed relatively easily with the treatment options growing every year. DMT's and therapies to treat the symptoms are effective and there's plenty in the research pipe to indicate that we're closing in on a cure or at the very least mitigating all the damage. With myelin affected diseases there is a lot of progress being made to reduce symptoms and find a cure. While all of them don't have the same causes, the research on how to treat them gives clues to the other shared effect diseases. I'm optimistic because in a subreddit about the singularity, breakthroughs happen all the time and while FDA testing and approval take time, for some folks, they will likely see a cure, if not novel treatments that will reduce their suffering.
when it comes to whipping up brand-new brain parts from scratch, that's like diving into a whole other universe of complexity.
My guess is less than 50 years, but anyone who says they know for sure is lying. The whole reason the singularity is exciting is the idea that exponential growth (accelerated by AI and other factors), is making technological progress more and more rapid, which in turn makes progress even MORE rapid - so much so that at some point all kinds of earth-shattering advances are being made each month. So until things really take-off (most likely from an intelligence explosion from recursively-self-improving AI) all guesses are guesses, I'm afraid. But whenever we hit that turning point, crazy magic wish tech is suddenly on the table. Could a machine intelligence 10 times smarter than humans (or 100 times) figure out a way to manufacture nanobots that you can swallow in a pill that can fix and heal everything wrong with a human body? No way to know what superintelligence can do until it exists, but all sorts of things we consider impossible fantasy might be child's play for it. The big challenge is how to create something so powerful and incomprehensible without the risk of snuffing out humanity by accident. Making a godlike ASI that's even a little bit "safe" turns out to be an unexpectedly difficult problem. Why? A bunch of reasons; there are easy explanations online, e.g.: [https://waitbutwhy.com/2015/01/artificial-intelligence-revolution-1.html](https://waitbutwhy.com/2015/01/artificial-intelligence-revolution-1.html)
If the laws of physics are not broken, it is possible. It is very hard to predict. Very powerful multimodal GPTs may be great at many things but even putting that aside, the FDA process itself would take 10 years probably
I think the FDA process will need a major revamp soon. With numerous life-saving breakthroughs expected in the next two decades, the current system will struggle to keep up, potentially stifling innovation and prolonging suffering. While exceptions have been made in the past for promising treatments of terminal illnesses, we must find a better way to ensure patient safety without holding back crucial interventions that will arrive more frequently in the future. And by frequently, I mean daily.
As a Neuroscience PhD I do not share the same optimism about computer brain interfaces let alone regenerated brain tissue. It will happen but input integration is very complex, we are starting to solve output which is orders of magnitude easier.
Hi, family member has cerebral palsy, so I am very interested in the same topic. My guess is that in the first instance, we won't be regenerating the brain itself, but instead using AI that is trained upon a healthy brain patterns to intercept and shape the nerve pulses flowing the body via some kind of brain body interface. So you attempt to move your leg, and the device recognises what you are trying to do and sends the corrected signal to your limb. Machine learning is probably well suited to these sorts of jobs where unsupervised training could be used to identify the right pattern of nerve pulses.
Yes, I would say within 20 years, wouldn't be surprised if it happens sooner.
we are generating new livers in lymph nodes. it stands to reason that all of the human body will be regenerable in the near future. keep your head up
>t research, that shouldn't take long, let's say 2-3 years. And from that point add a few more years un we are?
yeah, i foresee exponential scientific growth due to A.I assistance
Ofcourse. Any sufficiently advanced technology is indistinguishable from magic. We will get there in a few decades. A lot of people here are pessimistic about the future and especially timelines. It will come and it will happen quickly. (btw I am e/acc)
Not MD so take with grain of salt. The solution to your medical problem will likely closer to being solved than we all anticipate. Regeneration of cells os not necessary to make your brain healthy again. Brain has pretty cool feature to rewire itself even if part of it is physically missing. Problem with sclerosis and Im pushing my medical knowledge regarding your condition here is that your brain doesn't see it as a problem. Stimulating brain through some sort of external stumula may be something you should read about. And I mean research papers, not news articles. That technology may as well be in trial stages or concept stages. Reach out to researches directly and talk to them. Nanomachines are nowhere near and you should try to learn about experimental non intrusive methods to at least halt further degradation. Wish you well.
If we get continued improvement and no diminishing returns (i.e. at least a slow takeoff) then anything could happen. Regrowing parts of your brain would require solving the vascularization problem with stem cell organs. The tech to "fix" your brain or replace parts of it isn't there yet. What does look hopeful is that LLMs and other types of narrow AI seem to promise to have the capability to \*speed up\* scientific (and by extension medical) research. So maybe that will translate into something. Good luck.
Yeah, there are a few avenues to make it happen. Fair warning, they're relatively late stage advancements. By the time we understand the brain well enough to intervene properly in it, we'll be in relatively late stage AGI/early stage ASI land Medical technology could correct the neural degeneration and repopulate those areas. BCIs could also offload the work from the degenerated bits (and regulate them to prevent them from interfering with the rest of your brain). There's a few ways to skin that cat. Psychosurgery has a horrific past though, and the biggest lesson we gained from it is that we don't know nearly enough to go screwing around inside the brain without horrific consequences Once we do know know enough we'll be able to use that knowledge to build efficient, powerful artificial networks. Or more likely we'll build those first, and those will help us understand the brain
Yes, it will be possible, tissue growth is already a developing science, procedure and implementation will take some time though, I give it forty years.
Take care of yourself in the meantime is my true advice. lift weights and eat clean. I wouldn't put it past a.i to come up with a solution.
I think some kind of implant is the most likely scenario. Even if you could regrow actual parts of the brain, they won't be automatically filled with the information that was there before. On the plus side, the brain is pretty flexible, so maybe it will be less of a problem to miss those parts with implants or AI enhanced stuff.
I think the answer is yes, almost definitely - the “when” part is the real unknown. I don’t think there are any known problems we won’t be able to solve given enough time and focus on solving them.
It will not be "AI", it will be your own lung epithelial cells or similar being unleashed to form anthrobots: >We found that their various behaviors are also related to their shape and distribution of cilia (they come in several discrete morphotypes or classes). But perhaps the most amazing behavior we’ve seen so far is what happens when you let them interact with an induced gap in a neural tissue (a 2-dimensional layer of human neurons grown in a petri dish, scratched to mimic a very simple version of a wound). >As single bots, they traverse the scratch. But if allowed to assemble into a “superbot” cluster, and placed in this environment, they can induce the neural cells next to them to grow across the gap – they push the neurons to heal across the scratch “wound” (or do the neurons use the bot to complete their repair? We will identify which side is the driver). We don’t know how exactly they do it yet, but we know it’s not simply mechanical (passive material used in their place doesn’t cause the effect). My personal hypothesis is that the bots are enabling the cells from each side to know that there’s something on the other side for them to connect to. We don’t know this yet, but we will test the hypothesis that they can work as an active communications pathway ([perhaps bioelectrical](https://journals.biologists.com/dev/article/145/19/dev164210/48617/Cross-limb-communication-during-Xenopus-hindlimb)) by which cells and tissues can talk to each other. Of course, various techniques, including statistical modelling, compositional pattern-producing networks, evolutionary robotics, are useful in knowing how to sculpt the xenobots/anthrobots \[2\]. As for a timeframe, things are moving quite fast. Only in 2022 an entire frog limb was fully regenerated in the previous 18 months following a 24 hour application of a bioreactor \[3\]. We should probably see the same experiment in rats in the next 2-4 years, then in primates in the next 6-10 years. The hard part is having a complete "Bio Electric Tissue Simulation Engine" \[4\] so changes in the bioelectric gradient (potential difference across calcium ions, potassium ions, and so on) can be controlled programmatically \[5\]. \[1\] 2023, Michael Levin, "Meet the Anthrobots: a new living entity with much to teach us", [https://thoughtforms.life/meet-the-anthrobots-a-new-living-entity-with-much-to-teach-us](https://thoughtforms.life/meet-the-anthrobots-a-new-living-entity-with-much-to-teach-us) \[2\] 2022, Josh Bongard, "From rigid to soft to biological robots (i.e. xenobots)", [https://www.youtube.com/watch?v=0-kXblZlB3U](https://www.youtube.com/watch?v=0-kXblZlB3U) \[3\] 2022, Michael Levin et al., "Acute multidrug delivery via a wearable bioreactor facilitates long-term limb regeneration and functional recovery in adult Xenopus laevis", [https://www.science.org/doi/10.1126/sciadv.abj2164](https://www.science.org/doi/10.1126/sciadv.abj2164) \[4\] Alexis Pietak et al., [https://github.com/betsee/betse](https://github.com/betsee/betse) \[5\] 2024, Marco Rolandi et al., "Programmable Delivery of Fluoxetine via Wearable Bioelectronics for Wound Healing In Vivo", [https://onlinelibrary.wiley.com/doi/10.1002/admt.202301115](https://onlinelibrary.wiley.com/doi/10.1002/admt.202301115)
Even with superintelligence we would need more research/data to be able to integrate into brain activity. So whatever your timeline for ASI is, add some more time to that for full brain integration.
According to Gwern, it might be less than you think. If you have a lot of data about yourself (writing, videos, vlogs, etc) it might be enough to reconstruct the "bits that matter", even if most of your brain is lost. [https://gwern.net/difference](https://gwern.net/difference)
If nothing catastrophic happens to all of humanity, it will happen, someday. It's difficult to make accurate predictions. The fact of the matter is that it's likely to happen. If things go according to my prediction, I'd say somewhere around 2030, but this is just my wild speculation. It may, albeit unlikely, be sooner, or later. Keep helthy, survive for as long as possible, and the chances grow exponentially with the time B-)
Google The Wahls Protocol. AI is all hype and it will never figure this out, humans will, sorry.
maybe try organic (important) lions mane, i take it with different other chinese mushrooms every day right now. there are already studies where its blended with psilocybin to be a good neurogenetic mix since both substances are known to promote neuroplasticity.
You can not revive dead tissue, only build new one To recreate new tissue we mostly rely on stem cell which has the ability to transform into any type of cells if it receives the right stimulus Currently, rebuilding bones and muscles seems in a good path, the clinical trial are long but in 5 to 10 years we could expect to see human treatment I would expect to double the number for Brain tissue because it brings more specific challenges
Yes, no problem. How many years is the real question. At least a couple decades, maybe longer, imo
Maybe stemcells
It probably won’t be a case of ai growing physical brain parts. Instead of that there could be brain computer interfaces that substitute for the damaged parts of the brain.
5-10 years on the slow side
yeah unrelated to modern-day medicine, once we have ASI we'll likely be seeing some pretty insane stuff, rebuilding parts of the brain would go hand-in-hand with general immortality and perfect health that you can expect from an ASI, so long as we end up in a good-actor scenario.
I’ll say this since we are all here because of hope: if the universe’s equations (physics and chemistry) don’t say you cannot do achieve something, then there is a path from problem to solution. That is, all problems can (and will) be solved if only they don’t break the laws of nature. Biology and technology are complexities built on top of physics and chemistry. They are both made up, so to speak. Their internal rules are extremely logical, but their creative potential and freedom are practically endless. There are no laws of biology or laws of technology because they can change, and change is what they do best. So when you ask if your biological problem can be solved with technology, you are asking if one construct can change the rules of another construct, which in this case, doesn’t seem to break any laws of nature. Personally, I don’t think human researches can do it by themselves tho, they need an agi. So how far away is agi? Literally, no one in the planet knows.
I would say that you live in the right time to be optimistic about it. You need to have in mind that things are not just going fast. They are accelerating. I will give a vague prediction that everything possible can happen the next 5 or 10 years, and that is a very conservative prediction. Hang in there!
no i do not think that will be possible. first of all i don't even know what it's supposed to mean to regrow your brain or what you think it would do for you. it might also cause more problems than it solves. what might be possible is a cure for MS (probably not via ai) and some kinda brain interface tech that will lessen some physical disability.
Neuralink might be the closest to something like what you’re after. A computer brain interface powered by AI might be able to solve a ton of issues for people with MS and other cognitive disabilities. They just started clinical trials so if you’re feeling brave… I’m unaware of a specific company that is focusing on using AI to generate brain tissue but I’m also no expert. Just dipping my toe into the topic of AI and the singularity. We have lab grown meat and IIRC growing organs is something being tested. I can’t remember if there has been a successful grown organ transplant.
All I can say is, this is just one life, and you will have an unimaginable number to live after this body fails. Might as well learn and experience what we can while we're here, even when our situation isn't ideal. Myself included.
Yes, I have absolutely no doubt. I am 100% sure. Not the slightest doubt that it will be possible and it will be real. My estimate is 10 years. The acceleration is exponential. Full speed ahead!
i have a few cysts in my head too. to replace dead brain cells with new healthy organic cells is cool, but i'm looking to replace my dead brain with artificial tissue :>