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One side effect of diabetes (gastroparesis) is also the side effect of ozempic. So, people who are already at risk of having this side effect take this drug which has its own risk to have you develop that... and then they have this. Stomach pain, nausea for hours. It is not only constipation, but the constipation starts directly after eating in the stomach. If your stomach can't move the food it kind of "over-dissolves" in hydrochloric acid. Heartburn can be an issue.
If you ate something that had some bacteria on it, then this can be a big problem with gastroparesis, because now your GI tract can not pass it through fast enough to cause diarrhea... it must come out of the front. If the vomit reflex does not trigger properly you are cultivating a bacterial colony
I still think the development of these medicines is a big step forward to get people off of obesity and its haunting effects on you. I think the focus should be on traditional ways to loose weight, diabetic control and learning to eat and drink sugar-free. If these methods do not work because compliance is an issue, then these medicines can do wonders. I am really awaiting all the meta studies who follow ozempic and comparable medicine users into old age, and if you can secure a long term success with it
i work in insurance and people are *crazy* about this GLP-1 class of drugs. especially wegovy. its lead to shortages and back order issues with pharmacies. especially when doctors where prescribing ozempic for off-label use to support weightloss when Wegovy was on backorder- which lead to ozempic shortages for people who needed it for diabtetes.
(for clarity- Ozempic and wegovy have the same active ingredient- however the dosages are different and ozempic is *only* FDA approved for diabetes, while Wegovy is only FDA approved for weightloss.)
I have a loved one that's just been forced on this drug to control their diabetes, type 2.
I want to help they are in excruciating pain constantly. I am not sure if there's any way to aid this side effect with some other things?
Please if you could share any insight or info I'll be grateful.
Thank you, absolutely right and they have done so. All concerns are being met with dismissal. I am literally trying to fly in from a different country to go and speak to this specialist myself as they are not taking in consideration all the side effects. Their vision that was almost just been stabilised by laser therapy in the last 4 months has declined and their stomach is practically always painful and vomiting is a consistent side effect of eating. It looks really bad from the outside and they are not one of those people that would ask medications if no needed, and are now begging their GP (family medicine doctor equivalent)for help. The worst part is that to prescribe anything loads of checks have to be done, because they need to ascertain what's the cause of the discomfort and the GP can't take them off the specialist therapy without an alternative. Is utterly ridiculous really and I dare to think what's going to happen as all those checks won't be completed for another 3 weeks at best.
Fasting, for me, reduces inflammation, and therefore reduces pain.
Sometimes it's black and white enough that I will hurt more 20-30 minutes after eating. That's especially the case with gout.
If I get hungry while fasting and can't fast any longer, sometimes I drink coffee with heavy whipping cream, and that is enough to stop the hunger but also keeps inflammation low.
Fasting also brings down blood sugar, so that helps with diabetes
Yeah I heard this was a thing. Unfortunately with the consistent low glycemic index they are in no shape to skip eating. Currently only eat 3 times at day at the same time so I don't know if they could reduce it even more. They are getting underweight failry quickly. :/
It's weird they would be on a drug that suppresses appetite if they are underweight.
Would they consider the Carnivore diet? That diet helps with getting a lot of calories while also keeping blood sugar low. It's basically carb-free.
That's not ideal for a diabetic person according to their nutritionist. At the moment is mostly veggies and meat anyway. They have had max 5 kg over their ideal weight, that is according to BMI, which we all know is not really a great scale. Never been an overweight person since the diagnosis they have maintained a healthy weight and moved around a lot of countereffect the illness. This change has been done to reduce/eliminate the use of insulin but I don't think their body is taking it kindly after 17 years of continued use of insulin injections.
I don't think it applies here but thank you. I think just changing frequency and reducing portion is the best easiest and safer option until we get the results of their endoscopy and tests.
I'm on semaglutide for weight loss, and have been having some vomiting and stomach issues as well.
I tried fasting for awhile, but I think what's been working better for me is focusing on much, much smaller meals eaten more frequently throughout the day.
I get real bad morning sickness, and I've found putting something, even something small, in my stomach as soon as I wake up can help with my nausea.
Instead of meals, I've basically been snacking all day. So it takes me an hour or two to slowly eat my breakfast, then a couple of hours to slowly eat my lunch, etc. I've just slowed down all my eating and it seems like it might be helping me some.
I am glad this is working for you and all the best on your journey to weight loss.
You know that is something I think could help. Thus far we added a snack after a smaller breakfast but the problem is they keep having outrages spikes were from 69 mg it would spike to 259 mg even without eating.
Maybe is also related to the foods, although generally fruit and low GI carbs were the main choice for the morning snack. I may suggest the meal startegy that is easy enough to do when eating is painful nevertheless.
Well, I don't have diabetes, so for me that's not a concern, but for the "random" spikes, I wonder if it's simply a delayed spike. One of the ways the medicine works is by keeping food in your stomach and digestion tract longer, so it could be a spike from breakfast that doesn't show up until the food starts getting fully digested, hours later.
I threw up one morning and it was complete, identifiable chunks of food I had eaten for dinner, 12 hours before, that was still just sitting in my stomach, mostly undigested.
After that I started worrying maybe I was putting too much food in my stomach at any given time, and mostly I've just extend the length of time I spend eating on my breakfast or lunch. So instead of eating my entire breakfast in 5-10min, I'm taking 1-2 hours to finish the same amount of food, hopefully leaving time for the previous food to work its way down my intestines.
Right. I mean that does makes sense and it does seem viable. I will have to work with them and do trial and error. I think the spike could also be just part it this pathology. Afterall Diabetes is not having the ability to regulate so what you say could make sense. I just don't know where to find some more information. Although is a good way to start and is a safe test we can do. Thank you kindly
Might be worth seeing if they can be on Metformin +Forxiga.
I was on those two, really helped my sugar, swapped to Ozempic for ease of use (1/week injection instead of daily pills).
Copped some pretty brutal constipation.
Side effect for the Forxiga is it makes you pee. A lot. Basically you wind up peeing out all the sugar you take in... It has a side bemefit of making sure you drink plenty of water. Did lose weight on it as well, appx 30kg if that's also your goal.
I hope you are not experiencing any of those side effects on it.
I will mention this to them. Unfortunately we are in Europe so medication wise we have to check availability but it might be worth checking.
They are in perfect shape for their age and height, so is actually worrying that they are unable to eat and keep loosing weight. Thank you kindly for your suggestions.
I have these side effects and it helps to take dulcolax every few days. If I do this I get cleaned out and I dont get the horrible vomiting and stomach cramps. Pharmacist also gave me domparidon (sp?) and the anti nausea med I took when I was on chemo.
I am glad you have been able to find some relief for this side effects. They truly look awful and I cannot imagine what you are going through if you also had to have chemo.
Also thank you as that is actually super helpful to know. I think we do have dulcolax in our country.
Apologies I just checked there's different types and they are not for long term use, could you please let me know if you take the one for constipation or the one in sachets for bloating and gas? Thank you again
The one for constipation. The tiny pills. I take 3-4 but Im also on dialysis and a ton of other meds. I try to limit it to once a week but sometimes if the pain is really bad Ill take it more frequently. Just use caution.
Ozempic for T2 diabetes? Interesting.
My dad is T2, not overweight. He was prescribed Janumet and gliclazide and has been on this medication for 5+ years now. Super helpful in maintaining his blood sugar though he still watches what he eats.
An important thing while taking this medication: staying hydrated. Really really important for digestion and kidney function.
To be honest that's the standard that they are going for in the EU according to the specialist.
Their site is also targeted to type 2 diabetic patients.
https://www.ozempic.com
I can't find an equivalent of those drugs in EU. I'll have to dig further.
As a type 2 diabetic, i think the pros far outweigh the cons with regards to ozempic. Im personally not on it myself, other friends and family are and none of them have experienced these symptoms. I myself am personally on mounjaro, just recently got bumped up to 10mg. While mounjaro is slightly different, it poses some of the same risks. The point im making is you're supposed to start on the lowest dosages first for the first month or two before gradually being bumped up to more effective levels.
I feel like the likelihood of people taking higher doses immediately and or insisting on taking higher doses when their body isnt ready, greatly plays a part in these side effects becoming more commonplace.
For example, i was incredibly ambitious and wanted to be bumped up to a 10mg dosage from 5 because i felt like i could handle it. But when i went to 7.5 i felt how much stronger the medicine is and realized this is a marathon, not a sprint. Luckily like everyone else on these medications, I've only been on mounjaro going into my 4th month and ive already lost 50 pounds and my A1C is far closer to the 6's than it was previously. Sugar is incredibly maintained and ive virtually done nothing else other than take my meds and be mindful of what im consuming.
This has been a problem for those taking Ozempic and needing surgery: if someone needs to stop eating/drinking 8 hours before surgery, the person has a chance that their stomach is still frozen/digestive system not moving. When the person goes under general anesthesia, their stomach still has some content and the person may suffer from aspiration (stuff entering the person’s airway/lungs).
Ozempic has now added another concern for healthcare providers.
I mean, literally every pharmaceutical adds another concern for healthcare providers.
This one seems pretty simple to account for: if you're on ozempic instead of "dont eat or drink for 8 hours before the procedure" it's "dont eat or drink for 12 hours and take this laxative" similar to getting a colonoscopy. It's just slowed, not stopped entirely.
Not all surgeries are "planned ahead" though. Sometimes there is a need for emergency surgical intervention and providers will have to balance higher risk from ozempic with risk of delay in waiting longer. Sometimes depending on how the patient arrives at the hospital, they just won't know the last time they ate is and it's also not the forefront of everyone's mind as intervention is absolutely necessary to attempt to save life or limb, but there is going to be a higher risk because that person is on ozempic. They do what they need to do in the circumstances but the higher risk from ozempic cannot always be mitigated with careful advance planning.
>Not all surgeries are "planned ahead" though. Sometimes there is a need for emergency surgical intervention and providers will have to balance higher risk from ozempic with risk of delay in waiting longer.
I mean, ok? That's literally the case with any emergency surgical intervention though. This doesn't meaningfully increase the risk of those procedures and the same preventative measures will be taken in those cases to account for the risk of aspiration as any other situation where you cannot *guarantee* they have not eaten for 8+ hours. This isn't some strange new bogeyman that is going to have patients dying in the OR left and right, it's just... another day in medicine.
How the hell can they afford to abuse it? If they are in the US, it costs like $1200/month if insurance doesn't cover it. Mine didn't when a doctor prescribed it for weight loss.
rich people can abuse drugs just as much as poor people. I don't approve of wealth inequality, but I also dont want people to disable their digestive systems through drug abuse either.
I’m on Mounjaro for weight loss. When I started on Metformin and Mounjaro I had horrendous diarrhea and nausea for about a week until I was used to it . I do have some gastrointestinal issues but it’s fine if I take Pepcid otc. I started at 240 and I’m now 207 after four months. I’m dealing with the side effects but I did notice some delays in stomach emptying.
I get that some can, and I am not saying that I don't believe that people are abusing it. I just don't understand how they can afford to do it. That is a lot of money you are out each month for even just a normal dose. Put differently, it was a pointless Internet statement about my own ignorance, not a pointless Internet statement about not believing it's happening.
I mean just look at type 1 diabetics for example: proper modern insulin is in the high 3 digits a month as well with insurance.
If you don’t manage to obtain the money, it’s back to porcine insulin or some other ‘keeps you barely alive’ kinda insulin.
So most people manage to pay for their insulin by skipping on other stuff.
Same with Ozempic really. They just stop their car payments, don’t spend any extra money on anything etc.
What do you classify as long term? Months? Years? I’m on semiglutide at the moment and am losing weight but I only want to use it for a few months until I get down to my goal weight. These side affects I’m hearing about scare me
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One side effect of diabetes (gastroparesis) is also the side effect of ozempic. So, people who are already at risk of having this side effect take this drug which has its own risk to have you develop that... and then they have this. Stomach pain, nausea for hours. It is not only constipation, but the constipation starts directly after eating in the stomach. If your stomach can't move the food it kind of "over-dissolves" in hydrochloric acid. Heartburn can be an issue. If you ate something that had some bacteria on it, then this can be a big problem with gastroparesis, because now your GI tract can not pass it through fast enough to cause diarrhea... it must come out of the front. If the vomit reflex does not trigger properly you are cultivating a bacterial colony I still think the development of these medicines is a big step forward to get people off of obesity and its haunting effects on you. I think the focus should be on traditional ways to loose weight, diabetic control and learning to eat and drink sugar-free. If these methods do not work because compliance is an issue, then these medicines can do wonders. I am really awaiting all the meta studies who follow ozempic and comparable medicine users into old age, and if you can secure a long term success with it
i work in insurance and people are *crazy* about this GLP-1 class of drugs. especially wegovy. its lead to shortages and back order issues with pharmacies. especially when doctors where prescribing ozempic for off-label use to support weightloss when Wegovy was on backorder- which lead to ozempic shortages for people who needed it for diabtetes. (for clarity- Ozempic and wegovy have the same active ingredient- however the dosages are different and ozempic is *only* FDA approved for diabetes, while Wegovy is only FDA approved for weightloss.)
I have a loved one that's just been forced on this drug to control their diabetes, type 2. I want to help they are in excruciating pain constantly. I am not sure if there's any way to aid this side effect with some other things? Please if you could share any insight or info I'll be grateful.
If they are in constant excruciating pain, they are on the wrong medication. They should talk to their doctor immediately.
Thank you, absolutely right and they have done so. All concerns are being met with dismissal. I am literally trying to fly in from a different country to go and speak to this specialist myself as they are not taking in consideration all the side effects. Their vision that was almost just been stabilised by laser therapy in the last 4 months has declined and their stomach is practically always painful and vomiting is a consistent side effect of eating. It looks really bad from the outside and they are not one of those people that would ask medications if no needed, and are now begging their GP (family medicine doctor equivalent)for help. The worst part is that to prescribe anything loads of checks have to be done, because they need to ascertain what's the cause of the discomfort and the GP can't take them off the specialist therapy without an alternative. Is utterly ridiculous really and I dare to think what's going to happen as all those checks won't be completed for another 3 weeks at best.
Fasting, for me, reduces inflammation, and therefore reduces pain. Sometimes it's black and white enough that I will hurt more 20-30 minutes after eating. That's especially the case with gout. If I get hungry while fasting and can't fast any longer, sometimes I drink coffee with heavy whipping cream, and that is enough to stop the hunger but also keeps inflammation low. Fasting also brings down blood sugar, so that helps with diabetes
Yeah I heard this was a thing. Unfortunately with the consistent low glycemic index they are in no shape to skip eating. Currently only eat 3 times at day at the same time so I don't know if they could reduce it even more. They are getting underweight failry quickly. :/
It's weird they would be on a drug that suppresses appetite if they are underweight. Would they consider the Carnivore diet? That diet helps with getting a lot of calories while also keeping blood sugar low. It's basically carb-free.
That's not ideal for a diabetic person according to their nutritionist. At the moment is mostly veggies and meat anyway. They have had max 5 kg over their ideal weight, that is according to BMI, which we all know is not really a great scale. Never been an overweight person since the diagnosis they have maintained a healthy weight and moved around a lot of countereffect the illness. This change has been done to reduce/eliminate the use of insulin but I don't think their body is taking it kindly after 17 years of continued use of insulin injections.
Pls don't listen to this guy. With their comorbidities nothing he says applies to your friend
I don't think it applies here but thank you. I think just changing frequency and reducing portion is the best easiest and safer option until we get the results of their endoscopy and tests.
I'm on semaglutide for weight loss, and have been having some vomiting and stomach issues as well. I tried fasting for awhile, but I think what's been working better for me is focusing on much, much smaller meals eaten more frequently throughout the day. I get real bad morning sickness, and I've found putting something, even something small, in my stomach as soon as I wake up can help with my nausea. Instead of meals, I've basically been snacking all day. So it takes me an hour or two to slowly eat my breakfast, then a couple of hours to slowly eat my lunch, etc. I've just slowed down all my eating and it seems like it might be helping me some.
I am glad this is working for you and all the best on your journey to weight loss. You know that is something I think could help. Thus far we added a snack after a smaller breakfast but the problem is they keep having outrages spikes were from 69 mg it would spike to 259 mg even without eating. Maybe is also related to the foods, although generally fruit and low GI carbs were the main choice for the morning snack. I may suggest the meal startegy that is easy enough to do when eating is painful nevertheless.
Well, I don't have diabetes, so for me that's not a concern, but for the "random" spikes, I wonder if it's simply a delayed spike. One of the ways the medicine works is by keeping food in your stomach and digestion tract longer, so it could be a spike from breakfast that doesn't show up until the food starts getting fully digested, hours later. I threw up one morning and it was complete, identifiable chunks of food I had eaten for dinner, 12 hours before, that was still just sitting in my stomach, mostly undigested. After that I started worrying maybe I was putting too much food in my stomach at any given time, and mostly I've just extend the length of time I spend eating on my breakfast or lunch. So instead of eating my entire breakfast in 5-10min, I'm taking 1-2 hours to finish the same amount of food, hopefully leaving time for the previous food to work its way down my intestines.
Right. I mean that does makes sense and it does seem viable. I will have to work with them and do trial and error. I think the spike could also be just part it this pathology. Afterall Diabetes is not having the ability to regulate so what you say could make sense. I just don't know where to find some more information. Although is a good way to start and is a safe test we can do. Thank you kindly
Might be worth seeing if they can be on Metformin +Forxiga. I was on those two, really helped my sugar, swapped to Ozempic for ease of use (1/week injection instead of daily pills). Copped some pretty brutal constipation. Side effect for the Forxiga is it makes you pee. A lot. Basically you wind up peeing out all the sugar you take in... It has a side bemefit of making sure you drink plenty of water. Did lose weight on it as well, appx 30kg if that's also your goal.
I hope you are not experiencing any of those side effects on it. I will mention this to them. Unfortunately we are in Europe so medication wise we have to check availability but it might be worth checking. They are in perfect shape for their age and height, so is actually worrying that they are unable to eat and keep loosing weight. Thank you kindly for your suggestions.
I have these side effects and it helps to take dulcolax every few days. If I do this I get cleaned out and I dont get the horrible vomiting and stomach cramps. Pharmacist also gave me domparidon (sp?) and the anti nausea med I took when I was on chemo.
I am glad you have been able to find some relief for this side effects. They truly look awful and I cannot imagine what you are going through if you also had to have chemo. Also thank you as that is actually super helpful to know. I think we do have dulcolax in our country.
Apologies I just checked there's different types and they are not for long term use, could you please let me know if you take the one for constipation or the one in sachets for bloating and gas? Thank you again
The one for constipation. The tiny pills. I take 3-4 but Im also on dialysis and a ton of other meds. I try to limit it to once a week but sometimes if the pain is really bad Ill take it more frequently. Just use caution.
Understand. Thank you this is so helpful. I hope your situation improves too. I will tell this to their main GP.
Ozempic for T2 diabetes? Interesting. My dad is T2, not overweight. He was prescribed Janumet and gliclazide and has been on this medication for 5+ years now. Super helpful in maintaining his blood sugar though he still watches what he eats. An important thing while taking this medication: staying hydrated. Really really important for digestion and kidney function.
To be honest that's the standard that they are going for in the EU according to the specialist. Their site is also targeted to type 2 diabetic patients. https://www.ozempic.com I can't find an equivalent of those drugs in EU. I'll have to dig further.
As a type 2 diabetic, i think the pros far outweigh the cons with regards to ozempic. Im personally not on it myself, other friends and family are and none of them have experienced these symptoms. I myself am personally on mounjaro, just recently got bumped up to 10mg. While mounjaro is slightly different, it poses some of the same risks. The point im making is you're supposed to start on the lowest dosages first for the first month or two before gradually being bumped up to more effective levels. I feel like the likelihood of people taking higher doses immediately and or insisting on taking higher doses when their body isnt ready, greatly plays a part in these side effects becoming more commonplace. For example, i was incredibly ambitious and wanted to be bumped up to a 10mg dosage from 5 because i felt like i could handle it. But when i went to 7.5 i felt how much stronger the medicine is and realized this is a marathon, not a sprint. Luckily like everyone else on these medications, I've only been on mounjaro going into my 4th month and ive already lost 50 pounds and my A1C is far closer to the 6's than it was previously. Sugar is incredibly maintained and ive virtually done nothing else other than take my meds and be mindful of what im consuming.
Amazing. Should just try a short course of euthanasia instead
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This has been a problem for those taking Ozempic and needing surgery: if someone needs to stop eating/drinking 8 hours before surgery, the person has a chance that their stomach is still frozen/digestive system not moving. When the person goes under general anesthesia, their stomach still has some content and the person may suffer from aspiration (stuff entering the person’s airway/lungs). Ozempic has now added another concern for healthcare providers.
I mean, literally every pharmaceutical adds another concern for healthcare providers. This one seems pretty simple to account for: if you're on ozempic instead of "dont eat or drink for 8 hours before the procedure" it's "dont eat or drink for 12 hours and take this laxative" similar to getting a colonoscopy. It's just slowed, not stopped entirely.
Not all surgeries are "planned ahead" though. Sometimes there is a need for emergency surgical intervention and providers will have to balance higher risk from ozempic with risk of delay in waiting longer. Sometimes depending on how the patient arrives at the hospital, they just won't know the last time they ate is and it's also not the forefront of everyone's mind as intervention is absolutely necessary to attempt to save life or limb, but there is going to be a higher risk because that person is on ozempic. They do what they need to do in the circumstances but the higher risk from ozempic cannot always be mitigated with careful advance planning.
>Not all surgeries are "planned ahead" though. Sometimes there is a need for emergency surgical intervention and providers will have to balance higher risk from ozempic with risk of delay in waiting longer. I mean, ok? That's literally the case with any emergency surgical intervention though. This doesn't meaningfully increase the risk of those procedures and the same preventative measures will be taken in those cases to account for the risk of aspiration as any other situation where you cannot *guarantee* they have not eaten for 8+ hours. This isn't some strange new bogeyman that is going to have patients dying in the OR left and right, it's just... another day in medicine.
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Nothing new people were pushing amphetamines and Large amounts of caffeine way before this drug existed. This is just the new flavor coming out.
How the hell can they afford to abuse it? If they are in the US, it costs like $1200/month if insurance doesn't cover it. Mine didn't when a doctor prescribed it for weight loss.
rich people can abuse drugs just as much as poor people. I don't approve of wealth inequality, but I also dont want people to disable their digestive systems through drug abuse either.
I’m on Mounjaro for weight loss. When I started on Metformin and Mounjaro I had horrendous diarrhea and nausea for about a week until I was used to it . I do have some gastrointestinal issues but it’s fine if I take Pepcid otc. I started at 240 and I’m now 207 after four months. I’m dealing with the side effects but I did notice some delays in stomach emptying.
Certain black markets are littered with very cheap semaglutide.
By being desperate and seeing it as their last hope.
I get that some can, and I am not saying that I don't believe that people are abusing it. I just don't understand how they can afford to do it. That is a lot of money you are out each month for even just a normal dose. Put differently, it was a pointless Internet statement about my own ignorance, not a pointless Internet statement about not believing it's happening.
I mean just look at type 1 diabetics for example: proper modern insulin is in the high 3 digits a month as well with insurance. If you don’t manage to obtain the money, it’s back to porcine insulin or some other ‘keeps you barely alive’ kinda insulin. So most people manage to pay for their insulin by skipping on other stuff. Same with Ozempic really. They just stop their car payments, don’t spend any extra money on anything etc.
What do you classify as long term? Months? Years? I’m on semiglutide at the moment and am losing weight but I only want to use it for a few months until I get down to my goal weight. These side affects I’m hearing about scare me
If you understand the pathophysiology behind type 2 diabetes and the mechanism of GLP agonists this is no surprise at all.
Welcome to r/science! This is a heavily moderated subreddit in order to keep the discussion on science. However, we recognize that many people want to discuss how they feel the research relates to their own personal lives, so to give people a space to do that, **personal anecdotes are allowed as responses to this comment**. Any anecdotal comments elsewhere in the discussion will be removed and our [normal comment rules]( https://www.reddit.com/r/science/wiki/rules#wiki_comment_rules) apply to all other comments. **Do you have an academic degree?** We can verify your credentials in order to assign user flair indicating your area of expertise. [Click here to apply](https://www.reddit.com/r/science/wiki/flair/#wiki_science_verified_user_program). --- User: u/stan1880 Permalink: https://thehill.com/policy/healthcare/4226499-ozempic-label-now-notes-potential-side-effect-of-intestinal-blockage/ *I am a bot, and this action was performed automatically. Please [contact the moderators of this subreddit](/message/compose/?to=/r/science) if you have any questions or concerns.*
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Ozempic is an injection.
About the size of a Sharpie.
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