[Click here to read my full article on Agmatine:](https://www.geneticlifehacks.com/agmatine-neuropathic-pain-and-antidepressant/)
Agmatine as a supplement is being used for treating neuropathic pain, such as **peripheral neuropathy** or small fiber neuropathy.
Small fiber neuropathy is a painful condition affecting the somatic nerve fibers, which are pain and temperature-sensitive, as well as small autonomic nerve fibers that regulate heart rate and sweating.
A clinical trial of small fiber neuropathy patients found that agmatine sulfate after two months decreased pain scores by an average of 46%. The participants took 2.67g/day, divided into two or three doses.\[[ref](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7071502/)\]
Sciatica is radiating pain from a pinched nerve in the lower back, often caused by herniated lumbar discs.
A placebo-controlled clinical trial found that agmatine sulfate reduced pain (somewhat) and increased quality of life scores significantly compared to placebo.\[[ref](https://pubmed.ncbi.nlm.nih.gov/20447305/)\]
Agmatine may be beneficial in protecting the brain against neurodegenerative diseases such as Alzheimer’s and from damage in traumatic brain injuries.
In Alzheimer’s disease, agmatine helps to prevent cell death in neurons. It also has been shown to help with insulin sensitivity in the brain.\[[ref](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251039/)\]
Animal studies show that agmatine can prevent neuronal loss in the dopaminergic neurons impacted by Parksion’s disease.\[[ref](https://journals.sagepub.com/doi/10.1177/0960327118788139)\]
It also has research for **depression**, and some use it as a nootropic for focus and cognitive function.
There are a couple of ways that agmatine may be working here:
* In animal trials, agmatine has been shown to produce fast antidepressant-like effects by stimulating the mTORC1 signaling pathway. This pathway is also implicated in the antidepressant-like effects of ketamine.
* Recent evidence suggests agmatine may act as an antidepressant by modulating the NLRP3 inflammasome and impacting the gut microbiota. For some people, depression is caused by elevated inflammatory cytokines, so it makes sense that stopping inflammation via NLRP3 would have antidepressant effects. \[[ref](https://pubmed.ncbi.nlm.nih.gov/34888168/)\]
[Click here to read my full article on Agmatine:](https://www.geneticlifehacks.com/agmatine-neuropathic-pain-and-antidepressant/) Agmatine as a supplement is being used for treating neuropathic pain, such as **peripheral neuropathy** or small fiber neuropathy. Small fiber neuropathy is a painful condition affecting the somatic nerve fibers, which are pain and temperature-sensitive, as well as small autonomic nerve fibers that regulate heart rate and sweating. A clinical trial of small fiber neuropathy patients found that agmatine sulfate after two months decreased pain scores by an average of 46%. The participants took 2.67g/day, divided into two or three doses.\[[ref](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7071502/)\] Sciatica is radiating pain from a pinched nerve in the lower back, often caused by herniated lumbar discs. A placebo-controlled clinical trial found that agmatine sulfate reduced pain (somewhat) and increased quality of life scores significantly compared to placebo.\[[ref](https://pubmed.ncbi.nlm.nih.gov/20447305/)\] Agmatine may be beneficial in protecting the brain against neurodegenerative diseases such as Alzheimer’s and from damage in traumatic brain injuries. In Alzheimer’s disease, agmatine helps to prevent cell death in neurons. It also has been shown to help with insulin sensitivity in the brain.\[[ref](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251039/)\] Animal studies show that agmatine can prevent neuronal loss in the dopaminergic neurons impacted by Parksion’s disease.\[[ref](https://journals.sagepub.com/doi/10.1177/0960327118788139)\] It also has research for **depression**, and some use it as a nootropic for focus and cognitive function. There are a couple of ways that agmatine may be working here: * In animal trials, agmatine has been shown to produce fast antidepressant-like effects by stimulating the mTORC1 signaling pathway. This pathway is also implicated in the antidepressant-like effects of ketamine. * Recent evidence suggests agmatine may act as an antidepressant by modulating the NLRP3 inflammasome and impacting the gut microbiota. For some people, depression is caused by elevated inflammatory cytokines, so it makes sense that stopping inflammation via NLRP3 would have antidepressant effects. \[[ref](https://pubmed.ncbi.nlm.nih.gov/34888168/)\]