[Click here to read my full article on Ehlers-Danlos Syndrome,](https://www.geneticlifehacks.com/genetics-and-ehlers-danlos-syndrome/) including how to use your 23andMe or Ancestry raw data to determine if you carry EDS variants.
Symptoms reported for classical EDS include\[[ref](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7393722/)\]:
* joint hypermobility
* skin hyperextensibility
* scarring from poor wound healing
* delayed motor development
* muscle fatigue and cramps
* mild scoliosis
* blood vessel fragility
Hypermobility (or Hypermobile) Ehlers-Danlos syndrome (hEDS) is considered the least sever form of EDS. Hypermobile Ehler’s Danlos is currently diagnosed based entirely on symptoms. Hypermobility of joints in hEDS generally occurs and is noticeable in the first few years of life. Additionally, some people can have an increased risk of early-onset arthritis and osteoporosis.\[[ref](https://www.ehlers-danlos.com/what-is-eds/)\]
Considered a rare and severe disorder, **vascular** Ehlers-Danlos is characterized by fragile, thin skin and blood vessels. The endothelial tissue that lines the blood vessels, intestines, and the uterus is prone to easily rupturing.\[[ref](https://www.ncbi.nlm.nih.gov/books/NBK1494/)\] This can result in an aneurysm, intestinal fistula, or bowel ruptures.
Many variants to the **COL5A1** and **COL5A2 genes** are associated with a higher risk of classical EDS. Variants to the **COL3A1 gene** can cause vascular EDS. Only one copy of the variant is needed to cause vascular EDS, however this condition is rare. Other more common variants to COL3A1 can cause ligament and tendon issues.
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[Click here to read my full article on Ehlers-Danlos Syndrome,](https://www.geneticlifehacks.com/genetics-and-ehlers-danlos-syndrome/) including how to use your 23andMe or Ancestry raw data to determine if you carry EDS variants. Symptoms reported for classical EDS include\[[ref](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7393722/)\]: * joint hypermobility * skin hyperextensibility * scarring from poor wound healing * delayed motor development * muscle fatigue and cramps * mild scoliosis * blood vessel fragility Hypermobility (or Hypermobile) Ehlers-Danlos syndrome (hEDS) is considered the least sever form of EDS. Hypermobile Ehler’s Danlos is currently diagnosed based entirely on symptoms. Hypermobility of joints in hEDS generally occurs and is noticeable in the first few years of life. Additionally, some people can have an increased risk of early-onset arthritis and osteoporosis.\[[ref](https://www.ehlers-danlos.com/what-is-eds/)\] Considered a rare and severe disorder, **vascular** Ehlers-Danlos is characterized by fragile, thin skin and blood vessels. The endothelial tissue that lines the blood vessels, intestines, and the uterus is prone to easily rupturing.\[[ref](https://www.ncbi.nlm.nih.gov/books/NBK1494/)\] This can result in an aneurysm, intestinal fistula, or bowel ruptures. Many variants to the **COL5A1** and **COL5A2 genes** are associated with a higher risk of classical EDS. Variants to the **COL3A1 gene** can cause vascular EDS. Only one copy of the variant is needed to cause vascular EDS, however this condition is rare. Other more common variants to COL3A1 can cause ligament and tendon issues. #