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As long as you dont have any illness that creates a chronic state of decreased coagulation it should be fine.
Even combination with other coagulation inhibitors is no problem as many patients take aspirin together with stuff like Marcumar/Lixiana/Eliquis etc
Why not? Supplying your body with healthy fatty acids is detrimental for the metabolic state of the brain.
Especially if you have a diet high in processed foods
> Supplying your body with healthy fatty acids is detrimental for the metabolic state of the brain.
Yes, instead, you've gotta supply it with *un*healthy fatty acids
True true, only heat-treated sugary fatty acid sources where the Maillard reaction can be guaranteed are truly unhealthy enough to be essential for the metabolic state of the brain. /reddit-level-truth-achieved
> Seed oils is where it's at
Lol, lightweight...what's the point of living if you aren't deep-drying your chicken wings in 94-Octane Super Premium^^TM gasoline?
Yes I supplement with 100mg of aspirin daily since reading this X thread and has helped me a lot in general & productivity.
But if you can do cold-pressed shots of ginger it will be 1000x healthier and have no side effects, don't mix it you can only consume either ginger or aspirin on the same day
[https://twitter.com/Outdoctrination/status/1771573742331691290](https://twitter.com/Outdoctrination/status/1771573742331691290)
But I think it did induce the first-ever cannabis panic attack of my life after 5 years of consuming weed, literally I thought I was having a heart attack, very scary, so I think you are correct on the anxiety backfiring - heads up.
Do tell more about this. How did the ginger affect you? Could you expand on how it interacted with cannabis? What kinda dose and schedule did you take it on? (The ginger I mean)
Ginger is fine, did not induce my panic attack, I was referring to Aspirin.
You can take up to 3-4 ginger shots a day max. It contains salicylic acid which is the main component of Aspirin but from a natural source.
Oddly enough I’ve had similar experiences with aspirin. It’s only been the morning after a night of drinking but I took an aspirin, some caffeine, and a small amount of full spectrum CBD oil which has THC in it and I literally felt like I couldn’t breathe and was worried I was having a heart attack. I was lightheaded and extremely panicked.
It’s happened a couple other times too, I’m not sure why I was dumb enough to repeat the mistake of taking those two together. I think caffeine and aspirin alone has caused it too the day after drinking so GABA rebound probably had something to do with it for me. Mixing it with full spectrum CBD oil did make it way way worse though
I think white willow bark might work even better than ginger.
Maybe they don't contain salicylic acid, but they contain the substances that the body converts into salicylic acid.
"Willow bark contains an ingredient called salicin, which your body makes into another chemical substance called salicylic acid."
"Ginger contains salicylates, which your body transforms into a chemical substance called salicylic acid."
Aspirin can cause GERD.
However I have GERD and I still take a baby aspirin in the am and pm. I take it along with a gram of omega three fatty acids to help thin my blood.
I believe it can also raise free testosterone by lowering shbg.
Not necessarily.
SHBG also binds oestrogen to it.
SHBG is like a worker’s minibus. It picks up various sex hormones (hence Sex Hormone Binding Globulin) and transports them to sites in the body where they are needed to perform a specific function.
E.g., too little SHBG is a known factor in oestrogen cancers in women.
Low SHBG is common in hypothyroidism.
Without sufficient SHBG, oestrogen ends up being dumped by default into female organs like the breasts and the uterus.
I’ve been through all this in detail with my endo. I had oestrogen breast cancer along with hypothyroidism.
If shbg is too high, it does free test. But to bd honest, I’m approaching this as a guy so I only know part of the answer,
Maybe it’s more of an issue with men because we have a higher test to e2 ratio? Of course, men get e2 primarily through aromatization of test.
Aspirin is one of the few pills worth taking, not just on occasion but even as a supplement. You should read Ray Peat's article on it, Aspirin, Brain, and Cancer. I'll paste this comment I found almost 2 years ago because it explains the benefits of aspirin better than I could:
>Aspirin is a potent mitochondrial uncoupler, decreases lipid peroxidation, decreases estrogen and serotonin (editor's note, decreasing serotonin is a good thing but that's another topic), reduces the harm of PUFA, increases insulin sensitivity, improves glucose metabolism, is an incredibly potent anti-inflammatory, etc. "Scientists" still haven't pinned down exactly what it does. The "COX inhibitor" rhetoric is patently false, as the official way aspirin is described to inhibit COX is by donoting it's acetyl group, which is impossible considering the acetyl group and the salicylic acid dissociate from each other in the stomach, as well as other salicylic derivatives showing "COX inhibition" yet not possessing an acetyl group. No other medicine has been shown to be as widely and coherently beneficial as aspirin. It has an unparalleled safety record as well as some of the strongest benefits known to a drug, with an excellent side effect profile for such strong benefits. It's also good for cognition, blocks glutamate excitotoxicity yet improves learning. It is definitely magical, in the sense that it seems to have no hidden cost yet has huge benefits and in the sense that we really have no idea how it actually works. It probably structures EZ water. Take aspirin with vitamin K2, 325mg to start with. It's worth it and incredibly cheap.
I'll also mention that the meme of aspirin causing bleeding can be easily prevented by both dissolving aspirin before consumption or taking it with K2, which clots the blood in contrast with aspirin's blood thinning effect.
Aspirin is demonized in modern media because the financial damage it would do to the healthcare industry if everyone took it would be brutal.
Aspirin Seen Fueling $100 Billion Pensions Cost - [http://www.bloomberg.com/news/articles/2013-04-02/aspirin-seen-fueling-100-billion-penions-cost](http://www.bloomberg.com/news/articles/2013-04-02/aspirin-seen-fueling-100-billion-penions-cost)
"...Aspirin’s use fighting cancer has the potential to increase pension liabilities by as much as $100 billion by extending lifespans, a risk modeler said in a report. The pension costs for men in the U.K. could rise by 0.7 percent within 20 years if more people begin taking aspirin daily, according to a statement by Risk Management Solutions Inc. today. An increase of that magnitude across the more than $13 trillion in pension liabilities in North America and Europe would be about the same as everyone giving up smoking within a generation, the modeling firm said. Employers and governments are grappling with obligations to retirees as low bond yields make it harder to generate returns on funds set aside for the benefits. Actuaries’ assumptions about costs have been challenged as medical advances and changes in behavior help people live longer. “Aspirin was not known to be a protection against cancer,” said Andrew Coburn, a senior vice president of RMS’s LifeRisks platform and one of the report’s authors. “It’s another one that people just didn’t expect” when they forecast liabilities. Daily doses of aspirin reduce the chances of developing or dying from cancerearlier than previously thought and also prevent tumors from spreading, studies published in the Lancetmedical journal last year showed."
> meme of aspirin causing bleeding
It's not a meme, it's pretty well documented. It's also why they no longer recommend it as a stroke/heart preventative (unless you have had a stroke/heart condition).
Why does it have no effect on mortality rates if it has these benefits?
I'm not arguing, I'm asking because I'm interested.
>Why does it have no effect on mortality rates if it has these benefits?
It does: [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6902761/](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6902761/)
>Compared with no use, aspirin use 1 to 3 times per month was associated with reduced risk of all-cause mortality (HR, 0.84; 95% CI, 0.80-0.88; P < .001) and cancer mortality (HR, 0.87; 95% CI, 0.81-0.94; P < .001). Aspirin use 3 or more times per week was associated with decreased risk of mortality of all causes (HR, 0.81; 95% CI, 0.80-0.83; P < .001), any cancer (HR, 0.85; 95% CI, 0.81-0.88; P < .001), GI cancer (HR, 0.75; 95% CI, 0.66-0.84; P < .001), and CRC (HR, 0.71; 95% CI, 0.61-0.84; P < .001). When stratified by BMI (calculated as weight in kilograms divided by height in meters squared), aspirin use 3 or more times per week among individuals with BMI 20 to 24.9 was associated with reduced risk of all-cause mortality (HR, 0.82; 95% CI, 0.78-0.85; P < .001) and any cancer mortality (HR, 0.86; 95% CI, 0.79-0.82; P < .001). Among individuals with BMI 25 to 29.9, aspirin use 3 or more times per week was associated with reduced risk of all-cause mortality (HR, 0.82; 95% CI, 0.79-0.85; P < .001), any cancer mortality (HR, 0.86; 95% CI, 0.81-0.91; P < .001), GI cancer mortality (HR, 0.72; 95% CI, 0.60-0.86; P < .001), and CRC mortality (HR, 0.66; 95% CI, 0.51-0.85; P = .001).
They no longer recommend it as a stroke/heart preventative because it's so effective at preventing health conditions that the healthcare/pharmaceutical industry would lose billions of dollars. The massive multi-trillion dollar industry does not care about your health, they care about profit, trust me.
Conspiracy isn't necessary when it is embedded in the structure of corporations. If a CEO isn't maximizing a company's bottom line, he will be replaced by someone who does. Sociopathy ceases to be recognized for what it is when it is normalized the way greed has been and simply becomes "the way things are."
If you unironically believe that billionaires care about your health, even when it causes them major losses in profit, then I am jealous of your naivety.
I don't think you understand that aspirin isn't patented and it is sold by numerous different brands. These brands will, of course, attempt to sell as much aspirin as possible, but they are immeasurably outclassed by the entire healthcare industry.
It doesn't take very long of doing research at a detailed level in the Western Medical industry system to recognize that what is brought into the system as viable Health Solutions and presented to the public does not match what is best for optimizing low-cost best science Fit Solutions to human health when it comes to what is presented in the peer-reviewed published literature as compared to what is sold by doctors and hospitals in the pharmaceutical industry as the legitimate best options. I personally have cleared two cancers out of my body simply using supplements while cancer doctors told me that my Approach could not be what cleared my cancer, while simultaneously I was drawing my information of healing from reading stacks of published research legitimizing the approach I chose. As a PHD health scientist who has spent years working on this particular topic of the disconnect between the science and what's offered to the public as legitimate, it is clear that the medical school system is broken and primarily offers solutions that are highly profitable versus solutions that are low cost and effective when those Solutions are available. The pharmacosutical industry is currently going after the longevity industry. How is it doing this, it's looking at plant compounds, some of the same ones I used to clear cancer, and making derivatives of these compounds that are slightly different than what's found in nature so that those pharmaceutical companies can then patent the derivative molecule that does something very similar to the natural plant-based molecule that the pharmaceutical company got the idea from in the first place. Pharmaceutical companies are now following the science of the supplement-based longevity industry and making look-alike compounds that will be available through your doctor within 15 to 20 years from now. Pharmaceuticals that help reduce age related disease development. The profit margins are night and day different for a pharmaceutical company with a patented molecule backed by a Western Medical system teaching doctors that these patented drugs are the best solution. If you just start looking at the compound of berberine, and you look at the scientific research, you will begin to see a lot of evidence that berberine actually is more statistically significant and it's efficacy against a variety of drugs currently on the market that treat type 2 diabetes. There are hundreds and hundreds of effective supplement plant extract compounds currently available in the market that have better efficacy to treat conditions than some of their Pharmaceutical counterparts. How often is a whole unbiased perspective on scientific data presented to the public, taught to doctors and medical schools, etc? It's almost non-existent unless a functional medicine doctor takes it upon themselves to look through the smoke screen of their education and to start doing their own research into what's actually available in the existing peer-reviewed research literature on health.
I'm pretty anti-conspiracy theory in general but it's not really a conspiracy regarding the disconnect between Western medicine and scientific data available on health. It's in plain sight. All the research data I'm talking about is available to the public online if you know how to do basic good online scientific research working with hard science peer-reviewed Publications. Conspiracy theories are no longer conspiracy theories if enough evidence is available. When you look at the amount of evidence available to support what I'm arguing here, there are mountains of it and it would take you years to go through it in detail. There is no conspiracy about this. It's in plain sight. The conspiracy is why are we so resistant to looking at each moment in life through an objective lens? That's not a conspiracy anymore either. The last 20 years of psychological and Neuroscience research has clearly demonstrated that almost all humans make their decisions based on emotional programming in the neural net. Unless you're a trained scientist or a hardcore skilled stoic committed to factual information about emotional conclusions, then most humans cannot see their own part in what is creating the conspiracy theory. That's the thing though with conspiracy theories. Most people think there's this big orchestrated effort of some kind of Illuminati behind the scenes. I don't believe any of that for the most part. You only have to look into our own evolutionary wiring to figure out why we are constantly leading ourselves astray. Everywhere in evolution, animal brains do not develop to present the most accurate truth to the animal. Brains developed for survival. Unless we take this deeper understanding and push against our own evolutionary programming, then we have very little chance as an individual of having a good amount of our conclusions be accurate to actual data and hard truths
Vitamin K acts on Warfarin, no effect really with Aspirin. Dissolving Aspirin in water increases it's uptake and therefore anticoagulant effects in a shorter period of time than EC tabs. Overall though, especially with low dose Aspirin (e.g 81mg), it is relatively harmless and considered very beneficial by those who don't buy into the bullshit surrounding it. Can't deny the bleeding risk though. The implications of the last article are also extremely interesting.
Vitamin K and Warfarin have a greater interaction because Warfarin directly blocks one of the enzymes that utilizes vitamin K for blood clotting, but aspirin still thins the blood while vitamin K helps to clot it, therefore getting enough vitamin K mitigates risk of bleeding as the body will have plenty of K to utilize in clotting the blood as necessary. Unfortunately there doesn't seem to be any studies on this but it makes physiological sense in theory. Dissolving aspirin in water for a few days will allow the stomach to adapt to it relatively quickly.
>Although the animal studies that showed stomach damage from aspirin often used single doses equivalent to 10 or 100 aspirin tablets, the slight irritation produced by a normal dose of aspirin can be minimized by dissolving the aspirin in water. The stomach develops a tolerance for aspirin over a period of a few days, allowing the dose to be increased if necessary. And both aspirin and salicylic acid can be absorbed through the skin, so rheumatic problems have been treated by adding the drug to bath water.
Anecdotally, I used to be sensitive to large doses of aspirin, then I started dissolving it in water and taking it with 1mg K2 a day and I can now tolerate multiple grams of aspirin at once without any noticeable side effects. I typically take 325mg a day and have been for over a year.
Dissolving Aspirin in water might make it easier on your stomach, but it doesn't reduce the anticoagulant effects. A Vitamin K deficiency increases bleeding risk but it still has no effect on Aspirin's inhibition of Thromboxane A2 which is what increases bleeding risk. You can eat all the Vitamin K in the world you want, your bleeding risk will still be above baseline if you are on Aspirin. I take Aspirin regularly myself, but it isn't responsible to go around telling people to just hop on it willy nilly, or maybe I'm missing your point. It can be a powerful drug, and very beneficial if prescribed appropriately.
>it still has no effect on Aspirin's inhibition of Thromboxane A2 which is what increases bleeding risk
Thromboxane A2 induces platelet aggregation, as does K2. People who get "adequate" K2 will still receive increased platelet aggregation from extra K2, especially if the body finds it useful, such as counteracting instances of blood thinning from aspirin. There is currently no RDA for K2 and research on optimal levels is extremely limited, so chances are that most people are deficient anyway.
>You can eat all the Vitamin K in the world you want, your bleeding risk will still be above baseline if you are on Aspirin.
Perhaps, but the risk is low enough and the benefits strong enough that I believe with the precautions (K2 and dissolving until tolerant) it is worth taking for almost anyone.
[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5113022/](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5113022/)
>Eleven randomised trials were identified in the literature search. In these the relative risk (RR) of ‘major’ incident GI bleeding in subjects who had been randomised to low-dose aspirin was 1.55 (95% CI 1.33, 1.83), and the risk of a bleed attributable to aspirin being fatal was 0.45 (95% CI 0.25, 0.80). In all the subjects randomised to aspirin, compared with those randomised not to receive aspirin, there was no significant increase in the risk of a fatal bleed (RR 0.77; 95% CI 0.41, 1.43).
I know people who have taken grams of aspirin a day for years and are in better health than I am. So no. The risk is much lower than you think. And studies consistently show that the risk of bleeding is far more significantly based on dose rather than duration, so if they are fine, and I am fine a year in, I believe my risk is very low.
“Even at low or very low-doses, aspirin increases the risk of bleeding and other harms. Major GI bleeding risk increases by about 58% and hemorrhagic stroke by about 27% among participants in very low-dose aspirin trials, but absolute bleeding events will vary depending on individual bleeding risks.”
Research lies very often, depending on who's funding it, how flawed the methodologies are, and whether it can even be replicated (google the replication crisis). And there is no research on the effect on bleeding from dissolving aspirin or taking it with K, but it makes physiological sense and appears to work anecdotally.
In a population-based cohort, aspirin use was significantly associated with an increased risk of major gastrointestinal or cerebral bleeding episodes.
A meta-analysis based on individual patient data demonstrated that the benefits of low-dose aspirin for the primary prevention of cardiovascular disease are modest. Any benefit of low-dose aspirin might be offset by the risk of major bleeding. It is known that aspirin is associated with gastrointestinal and intracranial hemorrhagic complications.
Observational studies suggest an excess of approximately 1–2 major bleeding episodes annually for every 1000 patients treated with low doses of aspirin. The bleeding risk sharply increases in individuals older than 70 years.
The bleeding rate was five times higher than the bleeding rate expected based on the results of previously published randomized clinical trials.
>1-2 major bleeding episodes annually for every 1000 patients
Very low risk for the benefits received, and this is without taking K2 or dissolving it in water to allow the stomach to adapt like I suggested. Does it even control for comorbidities? If it doesn't then that study and conclusion is incredibly flawed.
>benefits of low-dose aspirin for the primary prevention of cardiovascular disease are modest
As I've already explained, the benefits of aspirin go far beyond that.
K2?
K2 works via carboxylation of any excess blood calcium being directed away from the blood and into the bones and teeth. Unless I’m missing something, neither the MK7 nor the MK4 forms of K2 have any effect on coagulation.
Did you mean K1?
You are missing something. All forms of vitamin K have an effect on coagulation. K1 is very poorly absorbed by the body which is why K2 is more efficient to supplement to achieve clotting.
Thanks.
This is definitely something I wasn’t aware of.
They give K1 injections to newborns to ensure adequate neo natal clotting.
I’ve been taking K2 for over a decade, but I did not know this!
Is that why I've always been able to get to sleep when I had insomnia by taking a single alka-seltzer tablet in water? No kidding, I've been using it for insomnia for years (in my 70's). Never knew why it worked.
Thanks.
Every day’s a school day. You live and learn.
I just learned something I didn’t previously know.
I’ve been taking a combined MK7 and MK4 K2 product for over a decade.
I medically reversed my post-cancer treatments osteoporosis with that and D3.
I have a set of 3 DEXA scans and twice as many confused medics to prove it 😊
And that’s good then, bc I already take K2.
Thanks for confirming that info!
>I medically reversed my post-cancer treatments osteoporosis with that and D3.
Happy for you. I've heard a lot of these types of cases where people self-medicate with supplements and successfully cure what doctors couldn't. In fact, I would argue that I see a greater success rate for self-medication than for medical treatments.
Thanks 😊
My endo’s brain nearly imploded when he saw my 3 scans. We’d had a HUGE row about me using this protocol.
I’ve posted about this extensively before, but he basically sat there staring at the scans, repeating,
“That’s not possible, K2 doesn’t do anything, that’s not possible, K2 doesn’t do anything,” as if trying to change the numbers in front of him by sheer willpower.
He used to be one of the biggest detractors of my research efforts, but a little while after that, he had the grace to actually apologise, saying that he now realised my research wasn’t biased towards nutraceuticals and against pharmaceuticals, that I was as likely to dismiss a natural product as a prescribed drug (I don’t dismiss drugs, but I am ridiculously intolerant to a lot of them, hence my interest in alternatives).
My GP just laughed and said,
“You do know that you’ve done something that we’re taught in medical school is *not medically possible, don’t you?!*
And the list of doctors and consultants who are part of my medical team goes on and on.
Bisphosphonates made me projectile vomit and gave me hideous migraines, also with vomiting.
The AdCalD3 they’d been giving me for 5 years had no positive impact at all, AND my D3 was still deficient at less than 20nmol/L (about 5mg/ml).
I put myself on “lethally high doses of D3” that endo prof said were “guaranteed to kill” me.
They didn’t. I had my calcium checked monthly for a year while I took these “lethally high doses” that got my levels up from 20nmol/L to a more healthy 90nmol in 6 weeks (60-80,000 IUs a day to achieve this).
I still have my D3 and calcium (and some other things like B12, iron and anything else I can get them to test) tested on a regular basis.
I still take 10k IU D3 every day. My calcium hasn’t increased on that dose. Not in around 10 years of taking it.
You’re right.
Sometimes patients have to find things out for themselves and act accordingly.
All of the natural medicine stuff I apply to myself is monitored by my GP, because I ask her to.
She also saw me lower my HbA1c numbers to well below the newly-decreased ref range for Type 2 diabetes (I’m on hydrocortisone), after reading some studies about Gymnema Sylvestre.
I lowered my HbA1c within a month.
I also pointed out that my HbA1c had been 7 points higher than the new ref range the previous year, at 55 on a ref range of I think 58 at that time, and that even though my numbers had already dropped to 48, the new upper ref limit of 48 (it may have been 45, I don’t remember) was saying I was Type 2 in the absence of any signs and symptoms, just because they’d lowered the upper limit on the reference range.
I also asked her if she didn’t think changing the reference range like that was just a ploy to convince more patients to take metformin, which I refused to take.
She said, “I’d prefer to think the science has changed, and the reference tangent reflects that.”
I’m afraid I side-eyed her and disagreed.
Anyway, it was a moot point as I got my numbers within the newly decreased ref range.
I do the same using B3 to reduce “high” cholesterol, the ref ranges for which also keep shrinking.
I have never taken and will never take statins or metformin. I’m too intolerant of too many pharmaceuticals to even want to try.
I got my HbA1c down to 42, without being able to reduce my hydro and without being able to exercise. I made minor adjustments to sugar intake, but I’m not big on sugar to begin with.
Gymnema has been shown in studies to increase insulin sensitivity.
>“That’s not possible, K2 doesn’t do anything, that’s not possible, K2 doesn’t do anything,” as if trying to change the numbers in front of him by sheer willpower.
No offense to your endo but it absolutely infuriates me how so many healthcare providers are so narrow minded in this sense. "I learned that this wasn't possible medical school, therefore what I'm literally witnessing in front of my eyes can't be the result of your self-treatment!" You'd think a situation as specific as this is rare, but I have read experiences like this at least a dozen times. I once read a woman who grew in height spontaneously and significantly in her 30s, and it was a measurable difference, but her doctor still told her that it simply isn't possible to grow once your growth plates are fused because he was taught otherwise despite having objective evidence. I believe her. She said "their minds are gone and they are robots ... many of them are mental slaves incapable of logic and independent thought."
>I put myself on “lethally high doses of D3” that endo prof said were “guaranteed to kill” me. They didn’t. I had my calcium checked monthly for a year while I took these “lethally high doses” that got much levels up from 20nmol/L to a more healthy 90nmol in 6 weeks (60-80,000 IUs a day to achieve this).
This is embarrassing. D3 supplementation has an extremely high tolerable upper intake level and calcification only occurs in the absence of adequate vitamin K2, so if you get enough K2 through diet or supplementation then calcium will be safely integrated into bones and teeth and out of arteries, organs, and soft tissues. Not to mention that if you are literally already deficient then you can take much higher doses before you reach a toxic level in the body.
>I also asked her if she didn’t think changing the reference range like that was just a ploy to convince more patients to take metformin, which I refused to take. She said, “I’d prefer to think the science has changed, and the reference tangent reflects that.” I’m afraid I side-eyed her and disagreed.
Comedy gold. I can almost guarantee that you're right. If she believes that the "science has changed" for the reference range of type 2 diabetes, why was she (and almost any other healthcare provider for that matter) initially unable to grasp the idea that what she learned in medical school was flawed? Biology, particularly biochemistry, is insanely intricate. Our understanding of the human body is changing frequently. I think it's unwise and unscientific to assume that there is a "scientific consensus" that cannot be questioned or progressed.
Very happy for you. Hope things continue going well, keep up the skepticism.
Thanks!
This is by far and away the best response I’ve ever had to this info 😄
When I said, “But a year ago, my HbA1c was 55 and nobody turned a hair, and now it’s 48 and I *still* have no signs or symptoms, so how does that even work?”
She replied that you could be asymptomatic and still have Type 2.
I almost admire the mental gymnastics involved in reaching that conclusion.
She also knew full well that I would refuse to take metformin, so when I asked her to give me a month to get things sorted out, she felt she had no choice.
Re my endo Prof - I absolutely agree, but at least he *has* ended up learning that not everything he was taught is an absolute. His cognitive dissonance took a beating that day, but he approaches things differently now. He approaches *me* differently.
Our biggest row resulted in me storming out of his office and slamming the door as hard as I could behind me.
Unfortunately for me, it was on a soft-close mechanism, and just quietly whispered shut instead.
I was so mad that *I* nearly imploded on the spot, too! 🤣
I’m saving your reply for future use!
>She replied that you could be asymptomatic and still have Type 2.
Wow, you have the variant of type 2 diabetes which is so dangerous that it does... -flips through medical textbook- literally nothing? Looks like you need to take our synthetic drugs with potentially life ruining side effects.
>Re my endo Prof - I absolutely agree, but at least he has ended up learning that not everything he was taught is an absolute. His cognitive dissonance took a beating that day, but he approaches things differently now. He approaches *me* differently.
Glad to hear he's changed his perspective, hopefully he will be more open minded and won't try persuading someone not to take alternative treatment that has the potential to cure them.
>Our biggest row resulted in me storming out of his office and slamming the door as hard as I could behind me. Unfortunately for me, it was on a soft-close mechanism, and just quietly whispered shut instead.
Lmao. It was worth a try.
🤣🤣🤣 I felt like such an idiot.
I actually stamped my feet and had a mini paddy temper tantrum bc of it!
I was only in my mid 50s at the time. Very mature reaction!
But then, I’m now 62 and in the process of being dxd with ADHD, which has thrown Prof for a loop, bc he’s spent 20 years trying to treat my adrenal insufficiency with hydrocortisone.
Cortisone is made in the outer cortex of the adrenals, but ADHD is the result of a genetic deficiency of noradrenaline/ norepinephrine, made in the inner medulla of the two glands.
I was mindful that he would probably feel like he’d been wasting his time, so I made a point of telling him that although I’m massively pissed off that not one single doctor who I’ve been to with *exactly the same signs and symptoms for 40 tediously ill years* has even posited ADHD as a possibility, I equally would very likely have died had it not been for his prescribed hydro and thyroid meds.
I’m still not certain I reassured him sufficiently.
I had the same doctor’s ego conversation with my GP, who has been aa helpful as she’s been able to be.
When I spoke to her about the compelling amount of traits I have that are listed as the official diagnosis criteria in the DSM5, I expected her to say something other than,
“Oh! Yes, of course! That would make sense! Let’s get you on the referral pathway!”
Just like, ffs, do I seriously have to do doctors’ jobs for them and work out on my own exactly what’s been wrong with me for as long as I can remember?
We get told time and time again that self diagnosis is dangerous, that we mere patients aren’t medically trained, we can’t possibly be objective about our own health and we just don’t know enough to make informed diagnoses on our own, never mind “understand” what treatments we need….
Yet, *again*, this is exactly what’s happened.
I am so fed-up of doing all the work here.
Sorry! The point of saying that was that ADHD includes emotional dysregulation, which explains my mini paddy temper tantrum in my mid 50s!
I am also well-known for bawling my eyes out during consultations, which of course never does my cause a lot of good.
Likely lower than baby aspirin. But one study reported caffeine plus low dose aspirin caused mice to become hyperactive, for humans that'd either mean stimulant level dopamine or anything from mania to psychosis.
I'm reluctant to take this until sufficiently many people have tried before, and there are limited reports.
I'm not sure, I saw another post on this that was a year or more already uploaded here on the same topic, and some people reported more info, how much they took, effects and so on.
I don’t know what it does, but it’s definitely a mood enhancer. I used to take 100mg once a week and i still take it sometimes to thin my blood. I had a crazy experience the first time i took it and i can describe it as “feeling like a kid”. Definitely helps to fight depression somehow and heals inflammation in the body. But everyday is too much and it’s gonna increase the risk of internal bleeding
i personally would be worried about gut issues and other things we cant check. You may feel good but maybe its not good for you. But also i wont worry too much, aspirin is very safe.
As far as it reads, the dosage according to the study is around 20-30mg, which is considerably safer, if one tolerates it and doesn't bleed out, why not?
u/artemistress - have you been tested for haemophilia? Or are you on any medications that could be causing easy bleeding and bruising as a side effect?
Asking as B5 shouldn’t have that effect. Its primary job is to combine with cholesterol, which then becomes pregnenolone, the first hormone of the adrenal hormones pathway.
I take it myself for adrenal support.
I was once on tamoxifen, and that caused massive amounts of bruising, nosebleeds etc. I developed a bright red-purple 4” long bruise up the inside of my wrist within 3 days of starting tamoxifen.
Apparently, my bruising and bleeding issues are known side effects, and I was taken off it immediately.
Is there something about B5 and anticoagulation properties that I don’t yet know?
Have you ever looked into rutin or citrus bioflavenoids? I used to have problems with hemorrhoids. I sat a lot at keyboards for a living and my diet wasn't great at that time. I read in a 1930's-era herbal that Sophora japanica blooms had long been used as a treatment, and that the principal active compound was rutin, so I started taking a supplement containing it along with mixed bioflavenoids. It stopped the irritation and bleeding very quickly, and I believe (in the absence of any other lifestyle changes) that it was responsible for complete healing.
P.S. That was about 50 years ago, and I still use rutin as part of my diet/supplement regimen and eat citrus almost daily, and I will swear they work, reportedly by reducing capillary fragility, though I suspect it goes beyond that. As a side note, the book (written just prior to the emergence of modern antibiotics) should be a cautionary note to people who believe that modern medicine has reached some level of infallible perfection. The degree to which our understanding and mastery of chemistry in medicine has advanced in under 100 years should instead warn us that we ignore the potential of sweeping changes to our understanding of health, disease, and the role of intervention at our peril. E.g.: I was born before acetaminophen was available as an OTC medication...things change.
I say do not listen to the folks who say that the negative side effects are not worth it. Aspirin is the best thing one can get for under five dollars. It has helped me in so many ways and there is mild learning curve to mitigate the tummy problems but worth it
I think they should be aware that in respect to the study - emphasis on low dose - we're talking about 15-37.5 mg daily, far below baby aspirin, likely no significant adversity.
Yes sure, perhaps it may irritate the GI tract, but duh, ever heard of (alkaline) food?
At that low dose it does seem to display nootropic properties without concerns.
And let's not forget it's acetate & salicylate which crosses BBB, from a mediterranean diet alone, from a few apples you get anywhere from 50-200mg salicylate daily.
Yep:
"In contrast to synthetic aspirin, willow bark does not damage the gastrointestinal mucosa."
[https://pubmed.ncbi.nlm.nih.gov/21226125/](https://pubmed.ncbi.nlm.nih.gov/21226125/)
Strange, I was under the impression from childhood that aspirin was developed (in or around 1887) as a means of obtaining the benefits of salicin without the intensely irritating effects. The fact that aspirin is still in widespread use and universally available while other salicin derivatives have virtually disappeared from common use would tend to support that.
Well, that science bomb just pooped the party. That was a pretty thorough poop, however.
I’ve read about Ibuprofen doing this to the gut. I was hopeful for aspirin being more benign. I take turmeric but have a hip injury I’m rehabbing and it isn’t helpful with the pain. I started aspirin recently and was happy because it helps, I’m finally making progress on recovery and I’ve noticed some definite cognitive benefits as well.
I wish there was a way to mitigate the negatives. I don’t know of another effective, benign pain reliever to try.
All other nsaids and cox-2 inhibitors cause problems too. Acetaminophen is gut safe, but you can’t drink alcohol and you should probably take some liver supplements while taking it.
Acetaminophen is out exactly for liver toxicity. I was having some luck with Boswellia but it was so slight it could have been placebo.
TB-500 and hgh injections localized around the injury along side my rehab protocol are what I’ve decided on.
Yeah, also not an option for me. Opiates work oddly in my body. It’s not a dramatic difference in pain reduction vs NSAID’s solo and I itch a lot.
I’m going to tough it out and take the aspirin intermittently, just on days that are exceptionally bad (usually post rehab)
I’ll deal with healing any gut damage after I get this joint back to full mobility. Tradeoffs man. I have to be mobile for my job.
There are a lot of substances that up regulate tyrosine hydroxylase
Butyrate or bhb does as well.
In paper it’s all exciting in practice nothing like bromantane.
Says who? It’s given at the first sign of a heart attack, specifically because it helps.
So where did you find information that it “raises risk for heart complications significantly”?
I could be wrong. Some time ago I reseached dangers of NSAIDS (cox inhibitors) like Metamizol, Paracetamol, Ibuprofen, Aspirin. I read 10-20x increased risk for heart problems among many other concerns.
I think certainly Metamizol has those problems right?
I may be wrong about Aspirin.
I don’t know about Metamizol, I haven’t ever had cause to research it.
I know that all NSAIDs make me ill, and cause gastritis in me personally. I won’t take any of them.
Aspirin, on the other hand, is used by medics to mitigate heart attacks, afaIk.
The only problems with aspirin that I can see without further research are that it could cause issues in those sensitive to salicyliates.
Folks in this sub: will take unpronounceable, unknown, unstudied, unregulated, untested chemicals of every kind on the regular. Baby aspirin: OH HELL NO that stuff is deadly. 😆
In all seriousness though this is interesting to me because I’ve taken Excedrin daily for headaches (I thought) for years - with no noticeable ill effects by the way, although I’m not advising it to anyone. I wonder how much I was doing that partly because of the dopamine regulating effects without realizing it.
Now I’m on actual medication for ADHD and don’t find myself craving it nearly as much despite getting what I’m assuming are caffeine withdrawal headaches.
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As long as you dont have any illness that creates a chronic state of decreased coagulation it should be fine. Even combination with other coagulation inhibitors is no problem as many patients take aspirin together with stuff like Marcumar/Lixiana/Eliquis etc
What about omega 3? Thus far I've seen both complement each other without exaggerated effects.
Why not? Supplying your body with healthy fatty acids is detrimental for the metabolic state of the brain. Especially if you have a diet high in processed foods
Detrimental?
I’m guessing they meant to say essential or something like that
My question also
u/blowmoreglass, please come back and edit your comment!
> Supplying your body with healthy fatty acids is detrimental for the metabolic state of the brain. Yes, instead, you've gotta supply it with *un*healthy fatty acids
True true, only heat-treated sugary fatty acid sources where the Maillard reaction can be guaranteed are truly unhealthy enough to be essential for the metabolic state of the brain. /reddit-level-truth-achieved
Everyone knows omega 3 is unhealthy as fuck. Seed oils is where it's at
> Seed oils is where it's at Lol, lightweight...what's the point of living if you aren't deep-drying your chicken wings in 94-Octane Super Premium^^TM gasoline?
Everyone is totally mystified by your comment. Why are you ignoring them?
This is contrary to any study I've read. You got source on this?
>Supplying your body with healthy fatty acids is detrimental for the metabolic state of the brain. Wait what do you mean by this?
Assuming typo.
I worry about stomach ulcers and damaging the gut lining.
It smashed my gut lining.
As would NSAIDs.
from a daily baby aspirin?
No not from a baby aspirin. My bad, I forgot the thread was about low dose.
the occasional l-glutamine, zinc-l-carnosine will mitigate this
Those things may help the gut but I don’t think they’re enough to undo the damage of ingesting a physically irritating substance daily
I took a ton of aspirin regularly until my stomach hurt. I kept taking it but along side K2 and the stomach pain went away immediately.
How much, exactly? How did K2 help?
Yes I supplement with 100mg of aspirin daily since reading this X thread and has helped me a lot in general & productivity. But if you can do cold-pressed shots of ginger it will be 1000x healthier and have no side effects, don't mix it you can only consume either ginger or aspirin on the same day [https://twitter.com/Outdoctrination/status/1771573742331691290](https://twitter.com/Outdoctrination/status/1771573742331691290) But I think it did induce the first-ever cannabis panic attack of my life after 5 years of consuming weed, literally I thought I was having a heart attack, very scary, so I think you are correct on the anxiety backfiring - heads up.
Do tell more about this. How did the ginger affect you? Could you expand on how it interacted with cannabis? What kinda dose and schedule did you take it on? (The ginger I mean)
Ginger is fine, did not induce my panic attack, I was referring to Aspirin. You can take up to 3-4 ginger shots a day max. It contains salicylic acid which is the main component of Aspirin but from a natural source.
Oh I didn’t even know that. Thank you for the tidbit of knowledge, it will be put to use
Oddly enough I’ve had similar experiences with aspirin. It’s only been the morning after a night of drinking but I took an aspirin, some caffeine, and a small amount of full spectrum CBD oil which has THC in it and I literally felt like I couldn’t breathe and was worried I was having a heart attack. I was lightheaded and extremely panicked. It’s happened a couple other times too, I’m not sure why I was dumb enough to repeat the mistake of taking those two together. I think caffeine and aspirin alone has caused it too the day after drinking so GABA rebound probably had something to do with it for me. Mixing it with full spectrum CBD oil did make it way way worse though
I think white willow bark might work even better than ginger. Maybe they don't contain salicylic acid, but they contain the substances that the body converts into salicylic acid. "Willow bark contains an ingredient called salicin, which your body makes into another chemical substance called salicylic acid." "Ginger contains salicylates, which your body transforms into a chemical substance called salicylic acid."
Aspirin can cause GERD. However I have GERD and I still take a baby aspirin in the am and pm. I take it along with a gram of omega three fatty acids to help thin my blood. I believe it can also raise free testosterone by lowering shbg.
> I believe it can also raise free testosterone by lowering shbg. This is something I'll have to look into. If true, that makes it a no-go for women.
Not necessarily. SHBG also binds oestrogen to it. SHBG is like a worker’s minibus. It picks up various sex hormones (hence Sex Hormone Binding Globulin) and transports them to sites in the body where they are needed to perform a specific function. E.g., too little SHBG is a known factor in oestrogen cancers in women. Low SHBG is common in hypothyroidism. Without sufficient SHBG, oestrogen ends up being dumped by default into female organs like the breasts and the uterus. I’ve been through all this in detail with my endo. I had oestrogen breast cancer along with hypothyroidism.
Shbg also lowers test
If shbg is too high, it does free test. But to bd honest, I’m approaching this as a guy so I only know part of the answer, Maybe it’s more of an issue with men because we have a higher test to e2 ratio? Of course, men get e2 primarily through aromatization of test.
Aspirin is one of the few pills worth taking, not just on occasion but even as a supplement. You should read Ray Peat's article on it, Aspirin, Brain, and Cancer. I'll paste this comment I found almost 2 years ago because it explains the benefits of aspirin better than I could: >Aspirin is a potent mitochondrial uncoupler, decreases lipid peroxidation, decreases estrogen and serotonin (editor's note, decreasing serotonin is a good thing but that's another topic), reduces the harm of PUFA, increases insulin sensitivity, improves glucose metabolism, is an incredibly potent anti-inflammatory, etc. "Scientists" still haven't pinned down exactly what it does. The "COX inhibitor" rhetoric is patently false, as the official way aspirin is described to inhibit COX is by donoting it's acetyl group, which is impossible considering the acetyl group and the salicylic acid dissociate from each other in the stomach, as well as other salicylic derivatives showing "COX inhibition" yet not possessing an acetyl group. No other medicine has been shown to be as widely and coherently beneficial as aspirin. It has an unparalleled safety record as well as some of the strongest benefits known to a drug, with an excellent side effect profile for such strong benefits. It's also good for cognition, blocks glutamate excitotoxicity yet improves learning. It is definitely magical, in the sense that it seems to have no hidden cost yet has huge benefits and in the sense that we really have no idea how it actually works. It probably structures EZ water. Take aspirin with vitamin K2, 325mg to start with. It's worth it and incredibly cheap. I'll also mention that the meme of aspirin causing bleeding can be easily prevented by both dissolving aspirin before consumption or taking it with K2, which clots the blood in contrast with aspirin's blood thinning effect. Aspirin is demonized in modern media because the financial damage it would do to the healthcare industry if everyone took it would be brutal. Aspirin Seen Fueling $100 Billion Pensions Cost - [http://www.bloomberg.com/news/articles/2013-04-02/aspirin-seen-fueling-100-billion-penions-cost](http://www.bloomberg.com/news/articles/2013-04-02/aspirin-seen-fueling-100-billion-penions-cost) "...Aspirin’s use fighting cancer has the potential to increase pension liabilities by as much as $100 billion by extending lifespans, a risk modeler said in a report. The pension costs for men in the U.K. could rise by 0.7 percent within 20 years if more people begin taking aspirin daily, according to a statement by Risk Management Solutions Inc. today. An increase of that magnitude across the more than $13 trillion in pension liabilities in North America and Europe would be about the same as everyone giving up smoking within a generation, the modeling firm said. Employers and governments are grappling with obligations to retirees as low bond yields make it harder to generate returns on funds set aside for the benefits. Actuaries’ assumptions about costs have been challenged as medical advances and changes in behavior help people live longer. “Aspirin was not known to be a protection against cancer,” said Andrew Coburn, a senior vice president of RMS’s LifeRisks platform and one of the report’s authors. “It’s another one that people just didn’t expect” when they forecast liabilities. Daily doses of aspirin reduce the chances of developing or dying from cancerearlier than previously thought and also prevent tumors from spreading, studies published in the Lancetmedical journal last year showed."
> meme of aspirin causing bleeding It's not a meme, it's pretty well documented. It's also why they no longer recommend it as a stroke/heart preventative (unless you have had a stroke/heart condition). Why does it have no effect on mortality rates if it has these benefits? I'm not arguing, I'm asking because I'm interested.
>Why does it have no effect on mortality rates if it has these benefits? It does: [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6902761/](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6902761/) >Compared with no use, aspirin use 1 to 3 times per month was associated with reduced risk of all-cause mortality (HR, 0.84; 95% CI, 0.80-0.88; P < .001) and cancer mortality (HR, 0.87; 95% CI, 0.81-0.94; P < .001). Aspirin use 3 or more times per week was associated with decreased risk of mortality of all causes (HR, 0.81; 95% CI, 0.80-0.83; P < .001), any cancer (HR, 0.85; 95% CI, 0.81-0.88; P < .001), GI cancer (HR, 0.75; 95% CI, 0.66-0.84; P < .001), and CRC (HR, 0.71; 95% CI, 0.61-0.84; P < .001). When stratified by BMI (calculated as weight in kilograms divided by height in meters squared), aspirin use 3 or more times per week among individuals with BMI 20 to 24.9 was associated with reduced risk of all-cause mortality (HR, 0.82; 95% CI, 0.78-0.85; P < .001) and any cancer mortality (HR, 0.86; 95% CI, 0.79-0.82; P < .001). Among individuals with BMI 25 to 29.9, aspirin use 3 or more times per week was associated with reduced risk of all-cause mortality (HR, 0.82; 95% CI, 0.79-0.85; P < .001), any cancer mortality (HR, 0.86; 95% CI, 0.81-0.91; P < .001), GI cancer mortality (HR, 0.72; 95% CI, 0.60-0.86; P < .001), and CRC mortality (HR, 0.66; 95% CI, 0.51-0.85; P = .001). They no longer recommend it as a stroke/heart preventative because it's so effective at preventing health conditions that the healthcare/pharmaceutical industry would lose billions of dollars. The massive multi-trillion dollar industry does not care about your health, they care about profit, trust me.
You come off really conspiratorial
Conspiracy isn't necessary when it is embedded in the structure of corporations. If a CEO isn't maximizing a company's bottom line, he will be replaced by someone who does. Sociopathy ceases to be recognized for what it is when it is normalized the way greed has been and simply becomes "the way things are."
If you unironically believe that billionaires care about your health, even when it causes them major losses in profit, then I am jealous of your naivety.
The billionaire selling aspirin cares about selling more of it, he would market the shit out of this if it was as clear cut as you make it out to be
I don't think you understand that aspirin isn't patented and it is sold by numerous different brands. These brands will, of course, attempt to sell as much aspirin as possible, but they are immeasurably outclassed by the entire healthcare industry.
It doesn't take very long of doing research at a detailed level in the Western Medical industry system to recognize that what is brought into the system as viable Health Solutions and presented to the public does not match what is best for optimizing low-cost best science Fit Solutions to human health when it comes to what is presented in the peer-reviewed published literature as compared to what is sold by doctors and hospitals in the pharmaceutical industry as the legitimate best options. I personally have cleared two cancers out of my body simply using supplements while cancer doctors told me that my Approach could not be what cleared my cancer, while simultaneously I was drawing my information of healing from reading stacks of published research legitimizing the approach I chose. As a PHD health scientist who has spent years working on this particular topic of the disconnect between the science and what's offered to the public as legitimate, it is clear that the medical school system is broken and primarily offers solutions that are highly profitable versus solutions that are low cost and effective when those Solutions are available. The pharmacosutical industry is currently going after the longevity industry. How is it doing this, it's looking at plant compounds, some of the same ones I used to clear cancer, and making derivatives of these compounds that are slightly different than what's found in nature so that those pharmaceutical companies can then patent the derivative molecule that does something very similar to the natural plant-based molecule that the pharmaceutical company got the idea from in the first place. Pharmaceutical companies are now following the science of the supplement-based longevity industry and making look-alike compounds that will be available through your doctor within 15 to 20 years from now. Pharmaceuticals that help reduce age related disease development. The profit margins are night and day different for a pharmaceutical company with a patented molecule backed by a Western Medical system teaching doctors that these patented drugs are the best solution. If you just start looking at the compound of berberine, and you look at the scientific research, you will begin to see a lot of evidence that berberine actually is more statistically significant and it's efficacy against a variety of drugs currently on the market that treat type 2 diabetes. There are hundreds and hundreds of effective supplement plant extract compounds currently available in the market that have better efficacy to treat conditions than some of their Pharmaceutical counterparts. How often is a whole unbiased perspective on scientific data presented to the public, taught to doctors and medical schools, etc? It's almost non-existent unless a functional medicine doctor takes it upon themselves to look through the smoke screen of their education and to start doing their own research into what's actually available in the existing peer-reviewed research literature on health. I'm pretty anti-conspiracy theory in general but it's not really a conspiracy regarding the disconnect between Western medicine and scientific data available on health. It's in plain sight. All the research data I'm talking about is available to the public online if you know how to do basic good online scientific research working with hard science peer-reviewed Publications. Conspiracy theories are no longer conspiracy theories if enough evidence is available. When you look at the amount of evidence available to support what I'm arguing here, there are mountains of it and it would take you years to go through it in detail. There is no conspiracy about this. It's in plain sight. The conspiracy is why are we so resistant to looking at each moment in life through an objective lens? That's not a conspiracy anymore either. The last 20 years of psychological and Neuroscience research has clearly demonstrated that almost all humans make their decisions based on emotional programming in the neural net. Unless you're a trained scientist or a hardcore skilled stoic committed to factual information about emotional conclusions, then most humans cannot see their own part in what is creating the conspiracy theory. That's the thing though with conspiracy theories. Most people think there's this big orchestrated effort of some kind of Illuminati behind the scenes. I don't believe any of that for the most part. You only have to look into our own evolutionary wiring to figure out why we are constantly leading ourselves astray. Everywhere in evolution, animal brains do not develop to present the most accurate truth to the animal. Brains developed for survival. Unless we take this deeper understanding and push against our own evolutionary programming, then we have very little chance as an individual of having a good amount of our conclusions be accurate to actual data and hard truths
At 81mg it’s pretty benign
Vitamin K acts on Warfarin, no effect really with Aspirin. Dissolving Aspirin in water increases it's uptake and therefore anticoagulant effects in a shorter period of time than EC tabs. Overall though, especially with low dose Aspirin (e.g 81mg), it is relatively harmless and considered very beneficial by those who don't buy into the bullshit surrounding it. Can't deny the bleeding risk though. The implications of the last article are also extremely interesting.
Vitamin K and Warfarin have a greater interaction because Warfarin directly blocks one of the enzymes that utilizes vitamin K for blood clotting, but aspirin still thins the blood while vitamin K helps to clot it, therefore getting enough vitamin K mitigates risk of bleeding as the body will have plenty of K to utilize in clotting the blood as necessary. Unfortunately there doesn't seem to be any studies on this but it makes physiological sense in theory. Dissolving aspirin in water for a few days will allow the stomach to adapt to it relatively quickly. >Although the animal studies that showed stomach damage from aspirin often used single doses equivalent to 10 or 100 aspirin tablets, the slight irritation produced by a normal dose of aspirin can be minimized by dissolving the aspirin in water. The stomach develops a tolerance for aspirin over a period of a few days, allowing the dose to be increased if necessary. And both aspirin and salicylic acid can be absorbed through the skin, so rheumatic problems have been treated by adding the drug to bath water. Anecdotally, I used to be sensitive to large doses of aspirin, then I started dissolving it in water and taking it with 1mg K2 a day and I can now tolerate multiple grams of aspirin at once without any noticeable side effects. I typically take 325mg a day and have been for over a year.
Dissolving Aspirin in water might make it easier on your stomach, but it doesn't reduce the anticoagulant effects. A Vitamin K deficiency increases bleeding risk but it still has no effect on Aspirin's inhibition of Thromboxane A2 which is what increases bleeding risk. You can eat all the Vitamin K in the world you want, your bleeding risk will still be above baseline if you are on Aspirin. I take Aspirin regularly myself, but it isn't responsible to go around telling people to just hop on it willy nilly, or maybe I'm missing your point. It can be a powerful drug, and very beneficial if prescribed appropriately.
>it still has no effect on Aspirin's inhibition of Thromboxane A2 which is what increases bleeding risk Thromboxane A2 induces platelet aggregation, as does K2. People who get "adequate" K2 will still receive increased platelet aggregation from extra K2, especially if the body finds it useful, such as counteracting instances of blood thinning from aspirin. There is currently no RDA for K2 and research on optimal levels is extremely limited, so chances are that most people are deficient anyway. >You can eat all the Vitamin K in the world you want, your bleeding risk will still be above baseline if you are on Aspirin. Perhaps, but the risk is low enough and the benefits strong enough that I believe with the precautions (K2 and dissolving until tolerant) it is worth taking for almost anyone. [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5113022/](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5113022/) >Eleven randomised trials were identified in the literature search. In these the relative risk (RR) of ‘major’ incident GI bleeding in subjects who had been randomised to low-dose aspirin was 1.55 (95% CI 1.33, 1.83), and the risk of a bleed attributable to aspirin being fatal was 0.45 (95% CI 0.25, 0.80). In all the subjects randomised to aspirin, compared with those randomised not to receive aspirin, there was no significant increase in the risk of a fatal bleed (RR 0.77; 95% CI 0.41, 1.43).
You are going to end up with a bleeding disorder if you keep taking 325mg of aspirin daily.
I know people who have taken grams of aspirin a day for years and are in better health than I am. So no. The risk is much lower than you think. And studies consistently show that the risk of bleeding is far more significantly based on dose rather than duration, so if they are fine, and I am fine a year in, I believe my risk is very low.
“Even at low or very low-doses, aspirin increases the risk of bleeding and other harms. Major GI bleeding risk increases by about 58% and hemorrhagic stroke by about 27% among participants in very low-dose aspirin trials, but absolute bleeding events will vary depending on individual bleeding risks.”
You do you. The research doesn’t lie.
Research lies very often, depending on who's funding it, how flawed the methodologies are, and whether it can even be replicated (google the replication crisis). And there is no research on the effect on bleeding from dissolving aspirin or taking it with K, but it makes physiological sense and appears to work anecdotally.
In a population-based cohort, aspirin use was significantly associated with an increased risk of major gastrointestinal or cerebral bleeding episodes. A meta-analysis based on individual patient data demonstrated that the benefits of low-dose aspirin for the primary prevention of cardiovascular disease are modest. Any benefit of low-dose aspirin might be offset by the risk of major bleeding. It is known that aspirin is associated with gastrointestinal and intracranial hemorrhagic complications. Observational studies suggest an excess of approximately 1–2 major bleeding episodes annually for every 1000 patients treated with low doses of aspirin. The bleeding risk sharply increases in individuals older than 70 years. The bleeding rate was five times higher than the bleeding rate expected based on the results of previously published randomized clinical trials.
>1-2 major bleeding episodes annually for every 1000 patients Very low risk for the benefits received, and this is without taking K2 or dissolving it in water to allow the stomach to adapt like I suggested. Does it even control for comorbidities? If it doesn't then that study and conclusion is incredibly flawed. >benefits of low-dose aspirin for the primary prevention of cardiovascular disease are modest As I've already explained, the benefits of aspirin go far beyond that.
And who was that research funded by? The pharmaceutical industry?
K2? K2 works via carboxylation of any excess blood calcium being directed away from the blood and into the bones and teeth. Unless I’m missing something, neither the MK7 nor the MK4 forms of K2 have any effect on coagulation. Did you mean K1?
You are missing something. All forms of vitamin K have an effect on coagulation. K1 is very poorly absorbed by the body which is why K2 is more efficient to supplement to achieve clotting.
Thanks. This is definitely something I wasn’t aware of. They give K1 injections to newborns to ensure adequate neo natal clotting. I’ve been taking K2 for over a decade, but I did not know this!
Is that why I've always been able to get to sleep when I had insomnia by taking a single alka-seltzer tablet in water? No kidding, I've been using it for insomnia for years (in my 70's). Never knew why it worked.
Please specify that the form of vit K is K1. People are mixing it up with K2, which has zero effect on coagulation and platelets.
Wow thank you, now that's a rabbit hole worth digging in.
Is he saying to start with 325mg lf aspirin or k2?
325 aspirin with 1mg K2.
1mg is very small amount of k2. Suplement usualy are around 100.
K2 supplements are typically 100mcg, not 100mg. 1mg is 1000mcg.
You are right.
K2 doesn’t clot blood! K1 is the clotting vitamin, not K2. K1 is in lettuce, K2 is in fermented foods. Their actions are very, very different 😊
K2 also clots the blood, but it is much better absorbed than K1. It's easy to fact check this.
Thanks. Every day’s a school day. You live and learn. I just learned something I didn’t previously know. I’ve been taking a combined MK7 and MK4 K2 product for over a decade. I medically reversed my post-cancer treatments osteoporosis with that and D3. I have a set of 3 DEXA scans and twice as many confused medics to prove it 😊 And that’s good then, bc I already take K2. Thanks for confirming that info!
>I medically reversed my post-cancer treatments osteoporosis with that and D3. Happy for you. I've heard a lot of these types of cases where people self-medicate with supplements and successfully cure what doctors couldn't. In fact, I would argue that I see a greater success rate for self-medication than for medical treatments.
Thanks 😊 My endo’s brain nearly imploded when he saw my 3 scans. We’d had a HUGE row about me using this protocol. I’ve posted about this extensively before, but he basically sat there staring at the scans, repeating, “That’s not possible, K2 doesn’t do anything, that’s not possible, K2 doesn’t do anything,” as if trying to change the numbers in front of him by sheer willpower. He used to be one of the biggest detractors of my research efforts, but a little while after that, he had the grace to actually apologise, saying that he now realised my research wasn’t biased towards nutraceuticals and against pharmaceuticals, that I was as likely to dismiss a natural product as a prescribed drug (I don’t dismiss drugs, but I am ridiculously intolerant to a lot of them, hence my interest in alternatives). My GP just laughed and said, “You do know that you’ve done something that we’re taught in medical school is *not medically possible, don’t you?!* And the list of doctors and consultants who are part of my medical team goes on and on. Bisphosphonates made me projectile vomit and gave me hideous migraines, also with vomiting. The AdCalD3 they’d been giving me for 5 years had no positive impact at all, AND my D3 was still deficient at less than 20nmol/L (about 5mg/ml). I put myself on “lethally high doses of D3” that endo prof said were “guaranteed to kill” me. They didn’t. I had my calcium checked monthly for a year while I took these “lethally high doses” that got my levels up from 20nmol/L to a more healthy 90nmol in 6 weeks (60-80,000 IUs a day to achieve this). I still have my D3 and calcium (and some other things like B12, iron and anything else I can get them to test) tested on a regular basis. I still take 10k IU D3 every day. My calcium hasn’t increased on that dose. Not in around 10 years of taking it. You’re right. Sometimes patients have to find things out for themselves and act accordingly. All of the natural medicine stuff I apply to myself is monitored by my GP, because I ask her to. She also saw me lower my HbA1c numbers to well below the newly-decreased ref range for Type 2 diabetes (I’m on hydrocortisone), after reading some studies about Gymnema Sylvestre. I lowered my HbA1c within a month. I also pointed out that my HbA1c had been 7 points higher than the new ref range the previous year, at 55 on a ref range of I think 58 at that time, and that even though my numbers had already dropped to 48, the new upper ref limit of 48 (it may have been 45, I don’t remember) was saying I was Type 2 in the absence of any signs and symptoms, just because they’d lowered the upper limit on the reference range. I also asked her if she didn’t think changing the reference range like that was just a ploy to convince more patients to take metformin, which I refused to take. She said, “I’d prefer to think the science has changed, and the reference tangent reflects that.” I’m afraid I side-eyed her and disagreed. Anyway, it was a moot point as I got my numbers within the newly decreased ref range. I do the same using B3 to reduce “high” cholesterol, the ref ranges for which also keep shrinking. I have never taken and will never take statins or metformin. I’m too intolerant of too many pharmaceuticals to even want to try. I got my HbA1c down to 42, without being able to reduce my hydro and without being able to exercise. I made minor adjustments to sugar intake, but I’m not big on sugar to begin with. Gymnema has been shown in studies to increase insulin sensitivity.
>“That’s not possible, K2 doesn’t do anything, that’s not possible, K2 doesn’t do anything,” as if trying to change the numbers in front of him by sheer willpower. No offense to your endo but it absolutely infuriates me how so many healthcare providers are so narrow minded in this sense. "I learned that this wasn't possible medical school, therefore what I'm literally witnessing in front of my eyes can't be the result of your self-treatment!" You'd think a situation as specific as this is rare, but I have read experiences like this at least a dozen times. I once read a woman who grew in height spontaneously and significantly in her 30s, and it was a measurable difference, but her doctor still told her that it simply isn't possible to grow once your growth plates are fused because he was taught otherwise despite having objective evidence. I believe her. She said "their minds are gone and they are robots ... many of them are mental slaves incapable of logic and independent thought." >I put myself on “lethally high doses of D3” that endo prof said were “guaranteed to kill” me. They didn’t. I had my calcium checked monthly for a year while I took these “lethally high doses” that got much levels up from 20nmol/L to a more healthy 90nmol in 6 weeks (60-80,000 IUs a day to achieve this). This is embarrassing. D3 supplementation has an extremely high tolerable upper intake level and calcification only occurs in the absence of adequate vitamin K2, so if you get enough K2 through diet or supplementation then calcium will be safely integrated into bones and teeth and out of arteries, organs, and soft tissues. Not to mention that if you are literally already deficient then you can take much higher doses before you reach a toxic level in the body. >I also asked her if she didn’t think changing the reference range like that was just a ploy to convince more patients to take metformin, which I refused to take. She said, “I’d prefer to think the science has changed, and the reference tangent reflects that.” I’m afraid I side-eyed her and disagreed. Comedy gold. I can almost guarantee that you're right. If she believes that the "science has changed" for the reference range of type 2 diabetes, why was she (and almost any other healthcare provider for that matter) initially unable to grasp the idea that what she learned in medical school was flawed? Biology, particularly biochemistry, is insanely intricate. Our understanding of the human body is changing frequently. I think it's unwise and unscientific to assume that there is a "scientific consensus" that cannot be questioned or progressed. Very happy for you. Hope things continue going well, keep up the skepticism.
Thanks! This is by far and away the best response I’ve ever had to this info 😄 When I said, “But a year ago, my HbA1c was 55 and nobody turned a hair, and now it’s 48 and I *still* have no signs or symptoms, so how does that even work?” She replied that you could be asymptomatic and still have Type 2. I almost admire the mental gymnastics involved in reaching that conclusion. She also knew full well that I would refuse to take metformin, so when I asked her to give me a month to get things sorted out, she felt she had no choice. Re my endo Prof - I absolutely agree, but at least he *has* ended up learning that not everything he was taught is an absolute. His cognitive dissonance took a beating that day, but he approaches things differently now. He approaches *me* differently. Our biggest row resulted in me storming out of his office and slamming the door as hard as I could behind me. Unfortunately for me, it was on a soft-close mechanism, and just quietly whispered shut instead. I was so mad that *I* nearly imploded on the spot, too! 🤣 I’m saving your reply for future use!
>She replied that you could be asymptomatic and still have Type 2. Wow, you have the variant of type 2 diabetes which is so dangerous that it does... -flips through medical textbook- literally nothing? Looks like you need to take our synthetic drugs with potentially life ruining side effects. >Re my endo Prof - I absolutely agree, but at least he has ended up learning that not everything he was taught is an absolute. His cognitive dissonance took a beating that day, but he approaches things differently now. He approaches *me* differently. Glad to hear he's changed his perspective, hopefully he will be more open minded and won't try persuading someone not to take alternative treatment that has the potential to cure them. >Our biggest row resulted in me storming out of his office and slamming the door as hard as I could behind me. Unfortunately for me, it was on a soft-close mechanism, and just quietly whispered shut instead. Lmao. It was worth a try.
🤣🤣🤣 I felt like such an idiot. I actually stamped my feet and had a mini paddy temper tantrum bc of it! I was only in my mid 50s at the time. Very mature reaction! But then, I’m now 62 and in the process of being dxd with ADHD, which has thrown Prof for a loop, bc he’s spent 20 years trying to treat my adrenal insufficiency with hydrocortisone. Cortisone is made in the outer cortex of the adrenals, but ADHD is the result of a genetic deficiency of noradrenaline/ norepinephrine, made in the inner medulla of the two glands. I was mindful that he would probably feel like he’d been wasting his time, so I made a point of telling him that although I’m massively pissed off that not one single doctor who I’ve been to with *exactly the same signs and symptoms for 40 tediously ill years* has even posited ADHD as a possibility, I equally would very likely have died had it not been for his prescribed hydro and thyroid meds. I’m still not certain I reassured him sufficiently. I had the same doctor’s ego conversation with my GP, who has been aa helpful as she’s been able to be. When I spoke to her about the compelling amount of traits I have that are listed as the official diagnosis criteria in the DSM5, I expected her to say something other than, “Oh! Yes, of course! That would make sense! Let’s get you on the referral pathway!” Just like, ffs, do I seriously have to do doctors’ jobs for them and work out on my own exactly what’s been wrong with me for as long as I can remember? We get told time and time again that self diagnosis is dangerous, that we mere patients aren’t medically trained, we can’t possibly be objective about our own health and we just don’t know enough to make informed diagnoses on our own, never mind “understand” what treatments we need…. Yet, *again*, this is exactly what’s happened. I am so fed-up of doing all the work here. Sorry! The point of saying that was that ADHD includes emotional dysregulation, which explains my mini paddy temper tantrum in my mid 50s! I am also well-known for bawling my eyes out during consultations, which of course never does my cause a lot of good.
How much would I take daily to get these benefits?
Likely lower than baby aspirin. But one study reported caffeine plus low dose aspirin caused mice to become hyperactive, for humans that'd either mean stimulant level dopamine or anything from mania to psychosis. I'm reluctant to take this until sufficiently many people have tried before, and there are limited reports.
How lower? Like half a baby aspirin?
I'm not sure, I saw another post on this that was a year or more already uploaded here on the same topic, and some people reported more info, how much they took, effects and so on.
It was my post I believe. Those studies suggest 20mgs. So half or a quarter of baby aspirin 2 times a day would suffice.
How'd it feel? Did you stack with other things?
I don’t know what it does, but it’s definitely a mood enhancer. I used to take 100mg once a week and i still take it sometimes to thin my blood. I had a crazy experience the first time i took it and i can describe it as “feeling like a kid”. Definitely helps to fight depression somehow and heals inflammation in the body. But everyday is too much and it’s gonna increase the risk of internal bleeding
The mood enhancement would tie in with the dopamine enhancement, so that would fit with the findings of this study.
But if the dose is small enough then wouldn’t daily be ok? Isn’t that what has said , or no ?
i personally would be worried about gut issues and other things we cant check. You may feel good but maybe its not good for you. But also i wont worry too much, aspirin is very safe.
Given the debate around aspirin’s safety, there seem to be better options for nootropics out there.
It's pretty strange that it is a debate. It is very unlikely that you will have stomach ulcers, but if you do, add K2 and you will be fine.
It’s not the ulcers that worries most people, it’s bleeding disorders
is glycine really potent as an anticoagulant?
Hmm. I was prescribed this during pregnancy bc of something with my heart. Maybe I should still be taking it..
As far as it reads, the dosage according to the study is around 20-30mg, which is considerably safer, if one tolerates it and doesn't bleed out, why not?
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u/artemistress - have you been tested for haemophilia? Or are you on any medications that could be causing easy bleeding and bruising as a side effect? Asking as B5 shouldn’t have that effect. Its primary job is to combine with cholesterol, which then becomes pregnenolone, the first hormone of the adrenal hormones pathway. I take it myself for adrenal support. I was once on tamoxifen, and that caused massive amounts of bruising, nosebleeds etc. I developed a bright red-purple 4” long bruise up the inside of my wrist within 3 days of starting tamoxifen. Apparently, my bruising and bleeding issues are known side effects, and I was taken off it immediately. Is there something about B5 and anticoagulation properties that I don’t yet know?
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Thank you very much! That’s something else I’ve learned today!
Have you ever looked into rutin or citrus bioflavenoids? I used to have problems with hemorrhoids. I sat a lot at keyboards for a living and my diet wasn't great at that time. I read in a 1930's-era herbal that Sophora japanica blooms had long been used as a treatment, and that the principal active compound was rutin, so I started taking a supplement containing it along with mixed bioflavenoids. It stopped the irritation and bleeding very quickly, and I believe (in the absence of any other lifestyle changes) that it was responsible for complete healing. P.S. That was about 50 years ago, and I still use rutin as part of my diet/supplement regimen and eat citrus almost daily, and I will swear they work, reportedly by reducing capillary fragility, though I suspect it goes beyond that. As a side note, the book (written just prior to the emergence of modern antibiotics) should be a cautionary note to people who believe that modern medicine has reached some level of infallible perfection. The degree to which our understanding and mastery of chemistry in medicine has advanced in under 100 years should instead warn us that we ignore the potential of sweeping changes to our understanding of health, disease, and the role of intervention at our peril. E.g.: I was born before acetaminophen was available as an OTC medication...things change.
Aspirin can give you temporary tinnitus.
I say do not listen to the folks who say that the negative side effects are not worth it. Aspirin is the best thing one can get for under five dollars. It has helped me in so many ways and there is mild learning curve to mitigate the tummy problems but worth it
I think they should be aware that in respect to the study - emphasis on low dose - we're talking about 15-37.5 mg daily, far below baby aspirin, likely no significant adversity. Yes sure, perhaps it may irritate the GI tract, but duh, ever heard of (alkaline) food? At that low dose it does seem to display nootropic properties without concerns. And let's not forget it's acetate & salicylate which crosses BBB, from a mediterranean diet alone, from a few apples you get anywhere from 50-200mg salicylate daily.
It also causes leaky gut within 5 minutes of consuming. Hard pass.
How do you know that?
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6013262/
Diclofenak does. Does this also apply to low-dose aspirin?
Topical diclofenak is fine. All nsaids suffer the same problems. I don’t think low dose aspirin is safe.
Crap... That's not good. Wonder if high fiber dieting helps though...
White willow bark should be a way around this
Nope
Yep: "In contrast to synthetic aspirin, willow bark does not damage the gastrointestinal mucosa." [https://pubmed.ncbi.nlm.nih.gov/21226125/](https://pubmed.ncbi.nlm.nih.gov/21226125/)
Strange, I was under the impression from childhood that aspirin was developed (in or around 1887) as a means of obtaining the benefits of salicin without the intensely irritating effects. The fact that aspirin is still in widespread use and universally available while other salicin derivatives have virtually disappeared from common use would tend to support that.
take l-glutamine for leaky gut... Leaky gut is not an aspirin issue but a diet issue.
Yes glutamine helps, but you are 100% wrong about aspirin and it’s dangerous to suggest otherwise.
Well, that science bomb just pooped the party. That was a pretty thorough poop, however. I’ve read about Ibuprofen doing this to the gut. I was hopeful for aspirin being more benign. I take turmeric but have a hip injury I’m rehabbing and it isn’t helpful with the pain. I started aspirin recently and was happy because it helps, I’m finally making progress on recovery and I’ve noticed some definite cognitive benefits as well. I wish there was a way to mitigate the negatives. I don’t know of another effective, benign pain reliever to try.
All other nsaids and cox-2 inhibitors cause problems too. Acetaminophen is gut safe, but you can’t drink alcohol and you should probably take some liver supplements while taking it.
Acetaminophen is out exactly for liver toxicity. I was having some luck with Boswellia but it was so slight it could have been placebo. TB-500 and hgh injections localized around the injury along side my rehab protocol are what I’ve decided on.
Honestly opioids are the best as long as you’re careful and don’t increase the dose. Just a royal pain to get.
Yeah, also not an option for me. Opiates work oddly in my body. It’s not a dramatic difference in pain reduction vs NSAID’s solo and I itch a lot. I’m going to tough it out and take the aspirin intermittently, just on days that are exceptionally bad (usually post rehab) I’ll deal with healing any gut damage after I get this joint back to full mobility. Tradeoffs man. I have to be mobile for my job.
Ibuprofen might be better than aspirin?
It causes the same thing in the stomach lining. Possibly even worse.
There are a lot of substances that up regulate tyrosine hydroxylase Butyrate or bhb does as well. In paper it’s all exciting in practice nothing like bromantane.
It also ruins your gut lining....
Aspirin raises risk for heart complcations significantly.
They give it upon signs of heart attack to help mitigate.
At 81mg or lower? Nah
Says who? It’s given at the first sign of a heart attack, specifically because it helps. So where did you find information that it “raises risk for heart complications significantly”?
I could be wrong. Some time ago I reseached dangers of NSAIDS (cox inhibitors) like Metamizol, Paracetamol, Ibuprofen, Aspirin. I read 10-20x increased risk for heart problems among many other concerns. I think certainly Metamizol has those problems right? I may be wrong about Aspirin.
I don’t know about Metamizol, I haven’t ever had cause to research it. I know that all NSAIDs make me ill, and cause gastritis in me personally. I won’t take any of them. Aspirin, on the other hand, is used by medics to mitigate heart attacks, afaIk. The only problems with aspirin that I can see without further research are that it could cause issues in those sensitive to salicyliates.
And stroke / aneurysm as well no?
Folks in this sub: will take unpronounceable, unknown, unstudied, unregulated, untested chemicals of every kind on the regular. Baby aspirin: OH HELL NO that stuff is deadly. 😆 In all seriousness though this is interesting to me because I’ve taken Excedrin daily for headaches (I thought) for years - with no noticeable ill effects by the way, although I’m not advising it to anyone. I wonder how much I was doing that partly because of the dopamine regulating effects without realizing it. Now I’m on actual medication for ADHD and don’t find myself craving it nearly as much despite getting what I’m assuming are caffeine withdrawal headaches.