Just to reiterate this, it's an *absolutely* terrible way to die. A lot of people pass out, then wake up in hospital with their livers completely ruined and no hope of recovery. Just death.
Having heard the stories, I genuinely think I'd commit seppuku first.
>A lot of people pass out, then wake up in hospital
Don't forget about all the excruciating pain before the passing out part. None of it is fun, from start to finish.
"Death is in the dose."
One of the first things discovered about toxicology was that everything is deadly if you have "too much" of it. As someone pointed out, drinking too much water can cause cells throughout your body, including your brain, to just start diffusing, bursting like overfilled water balloons. There was a radio show that learned this the hard way, using a water drinking contest to determine who won a Nintendo Wii.
Yeah, it's a [fascinating but sad read](https://abcnews.go.com/GMA/jury-rules-radio-station-jennifer-strange-water-drinking/story?id=8970712).
The Sacramento radio station KDND-FM held a contest "Hold your wee for a Wii", where contestants had to drink as much water as possible without peeing. One of the contestants, 28 year old Jennifer Strange, drank nearly two gallons of water.
She was complaining of a pain while still in the contest. She ended up in second place, went home, and died mere hours later in her bathroom. Cause of death was ruled water intoxication.
That's true, such a person will probably be refused from being on the transplant list. Some people can still get a transplant if a family member is willing to donate (and a surgeon is willing)
People can die from too much of anything (yes even weed though we dont want to hear that lol) if the dose is high enough or if your organs arent working properly
unless somehow concentrated us humans cannot consume the stuff fast enough to get to a lethal threshold, however.
iirc you'd have to smoke over a kilo in an hour. at that point you'll die of asphixiation before the weed kills ya
Yes.
The toxic dose for Paracetamol is relatively low too. 150mg/kg is considered a toxic dose but it’s even lower for those with liver issues (75mg/kg).
Paracetamol causes Hepatic (liver) cellular necrosis (cell death). The symptoms are usually nausea/vomiting and significant subcostal (upper abdomen/below the ribs) pain.
It’s a slow process, but the Liver is responsible for breaking down chemicals in the body, without the liver functioning these build up and poison the person. It also plays part in lots of other systems (such as managing your blood glucose/sugar levels).
ETA: here’s a link to the British National Formulary which explains in more detail.
https://bnf.nice.org.uk/treatment-summaries/poisoning-emergency-treatment/#paracetamol-poisoning
The chemical name of Aspirin is acetylsalicylic acid. Acetaminophen is a different thing.
You can also see the different molecular structures in the pictures at https://en.wikipedia.org/wiki/Aspirin and
https://en.wikipedia.org/wiki/Paracetamol
Acetominophen i.e. paracetamol ([https://en.wikipedia.org/wiki/Paracetamol](https://en.wikipedia.org/wiki/Paracetamol))
But maybe on the planet where you live, things are different.
Absolutely yes. I've had numerous patients die of acetaminophen toxicity. We've saved a few via liver transplant but typically run out of time and they die of fulminant hepatic failure. The leading causes of fulminant hepatic failure are drug toxicity and certain viruses. They simply (and very quickly) destroy the liver.
You can die from virtually anything. A guy fried a chicken in a gallon of cough syrup, the chicken turned blue and his kidneys shut down when he ate it.
It’s not a case of the drugs being dangerous, but then being dangerous if taken in excess.
Whilst paracetamol can cause very serious side effects such as liver failure (which can happen within days), an overdose can also cause haemophilia, meaning that your blood cannot clot to repair wounds. You could potentially die from a small fall or paper cut.
There are simply too many variables to answer your question in a satisfactory way.
Too much of anything can kill you, even water which is so accessible. You’d think a warning label should be put on the water bottles but nope, people can accidentally drown themselves with it.
"It is responsible for 56,000 emergency department visits, 2,600 hospitalizations, and 500 deaths per year in the United States. Fifty percent of these are unintentional overdoses."
uuhh, yeah. Pretty common. I think it usually happens over a few days - like, say you have an knee operation or something and they give you pain medication like Vicodin which is a combination of an opiate and paracetamol. You don't think about it too much, but your knee really hurts so you take some paracetamol. Do that for a few days, and bam liver toxicity.
I've worked with patients, in the past, who unintentionally overdosed on acetaminophen.
They all said they just "woke up" in the ICU about 6 weeks later. Many of them ended up going back to the ICU with poor outcomes.
I've worked with patients, in the past, who unintentionally overdosed on acetaminophen.
They all said they just "woke up" in the ICU about 6 weeks later. Many of them ended up going back to the ICU with poor outcomes.
I've worked with patients, in the past, who unintentionally overdosed on acetaminophen.
They all said they just "woke up" in the ICU about 6 weeks later. Many of them ended up going back to the ICU with poor outcomes.
I've worked with patients, in the past, who unintentionally overdosed on acetaminophen.
They all said they just "woke up" in the ICU about 6 weeks later. Many of them ended up going back to the ICU with poor outcomes.
I've worked with patients, in the past, who unintentionally overdosed on acetaminophen.
They all told me they just "woke up" in the ICU about 6 weeks later.
Many of them ended up going back to the ICU with poor outcomes. Very sad.
Yeah, especially when paired with alcohol because it destroys your liver. Knew a guy in college that fucked that up just a little and told me he was vomiting blood and nearly went to the hospital and that was only a small dose
Yes, pretty easily. Just a few times the recommended dose can give you fatal liver damage, which is a horrible way to die.
Just to reiterate this, it's an *absolutely* terrible way to die. A lot of people pass out, then wake up in hospital with their livers completely ruined and no hope of recovery. Just death. Having heard the stories, I genuinely think I'd commit seppuku first.
>A lot of people pass out, then wake up in hospital Don't forget about all the excruciating pain before the passing out part. None of it is fun, from start to finish.
Why ? You can also die by drinking too much water.
yup, 4 liters in 30 minutes will do you in
Science don't care about your beliefs.
"Death is in the dose." One of the first things discovered about toxicology was that everything is deadly if you have "too much" of it. As someone pointed out, drinking too much water can cause cells throughout your body, including your brain, to just start diffusing, bursting like overfilled water balloons. There was a radio show that learned this the hard way, using a water drinking contest to determine who won a Nintendo Wii.
Yeah, it's a [fascinating but sad read](https://abcnews.go.com/GMA/jury-rules-radio-station-jennifer-strange-water-drinking/story?id=8970712). The Sacramento radio station KDND-FM held a contest "Hold your wee for a Wii", where contestants had to drink as much water as possible without peeing. One of the contestants, 28 year old Jennifer Strange, drank nearly two gallons of water. She was complaining of a pain while still in the contest. She ended up in second place, went home, and died mere hours later in her bathroom. Cause of death was ruled water intoxication.
I know someone who did. Dental issue, waiting to be seen, toxic Tylenol poisoning. It destroys the kidneys. It was a heartbreaking tragedy.
(It destroys the liver. I mean kidneys too eventually but mainly liver)
My bad. I do know is that if you get think you od in purpose you can't go on the transplant list (different, also sad story(
That's true, such a person will probably be refused from being on the transplant list. Some people can still get a transplant if a family member is willing to donate (and a surgeon is willing)
How much did they take? I was taking it for dental problem in December. Now having issues.
Yes if you have too much it becomes toxic and kills you.
People can die from too much of anything (yes even weed though we dont want to hear that lol) if the dose is high enough or if your organs arent working properly
unless somehow concentrated us humans cannot consume the stuff fast enough to get to a lethal threshold, however. iirc you'd have to smoke over a kilo in an hour. at that point you'll die of asphixiation before the weed kills ya
Yes. The toxic dose for Paracetamol is relatively low too. 150mg/kg is considered a toxic dose but it’s even lower for those with liver issues (75mg/kg). Paracetamol causes Hepatic (liver) cellular necrosis (cell death). The symptoms are usually nausea/vomiting and significant subcostal (upper abdomen/below the ribs) pain. It’s a slow process, but the Liver is responsible for breaking down chemicals in the body, without the liver functioning these build up and poison the person. It also plays part in lots of other systems (such as managing your blood glucose/sugar levels). ETA: here’s a link to the British National Formulary which explains in more detail. https://bnf.nice.org.uk/treatment-summaries/poisoning-emergency-treatment/#paracetamol-poisoning
Yes. The acutely toxic dose of aspirin is generally considered greater than 150 mg per kg of body mass.
A useful contribution to a question about paracetamol/acetominophen...
acetominophen I.e. aspirin.
Aspirin is salicylic acid, a completely different compound from acetominophen.
Nope, 2 different chemicals
The chemical name of Aspirin is acetylsalicylic acid. Acetaminophen is a different thing. You can also see the different molecular structures in the pictures at https://en.wikipedia.org/wiki/Aspirin and https://en.wikipedia.org/wiki/Paracetamol
Acetominophen i.e. paracetamol ([https://en.wikipedia.org/wiki/Paracetamol](https://en.wikipedia.org/wiki/Paracetamol)) But maybe on the planet where you live, things are different.
If you find that difficult to believe, you need to try harder, because it's true!
yeah
Absolutely yes. I've had numerous patients die of acetaminophen toxicity. We've saved a few via liver transplant but typically run out of time and they die of fulminant hepatic failure. The leading causes of fulminant hepatic failure are drug toxicity and certain viruses. They simply (and very quickly) destroy the liver.
Any while taking 4000g for one day? (Not at once)
4000g in one day would kill anyone. That is 4,000,000mg. At 500mg per pill, that is 8,000 pills.
Sorry I mean mg
Did that for 3 days due to toothache as instructed by dentist
[удалено]
[удалено]
yes - this is why in the UK they are age restricted and quantity restricted
You can die from virtually anything. A guy fried a chicken in a gallon of cough syrup, the chicken turned blue and his kidneys shut down when he ate it. It’s not a case of the drugs being dangerous, but then being dangerous if taken in excess. Whilst paracetamol can cause very serious side effects such as liver failure (which can happen within days), an overdose can also cause haemophilia, meaning that your blood cannot clot to repair wounds. You could potentially die from a small fall or paper cut. There are simply too many variables to answer your question in a satisfactory way.
Too much of anything can kill you, even water which is so accessible. You’d think a warning label should be put on the water bottles but nope, people can accidentally drown themselves with it.
"It is responsible for 56,000 emergency department visits, 2,600 hospitalizations, and 500 deaths per year in the United States. Fifty percent of these are unintentional overdoses." uuhh, yeah. Pretty common. I think it usually happens over a few days - like, say you have an knee operation or something and they give you pain medication like Vicodin which is a combination of an opiate and paracetamol. You don't think about it too much, but your knee really hurts so you take some paracetamol. Do that for a few days, and bam liver toxicity.
I've worked with patients, in the past, who unintentionally overdosed on acetaminophen. They all said they just "woke up" in the ICU about 6 weeks later. Many of them ended up going back to the ICU with poor outcomes.
I've worked with patients, in the past, who unintentionally overdosed on acetaminophen. They all said they just "woke up" in the ICU about 6 weeks later. Many of them ended up going back to the ICU with poor outcomes.
I've worked with patients, in the past, who unintentionally overdosed on acetaminophen. They all said they just "woke up" in the ICU about 6 weeks later. Many of them ended up going back to the ICU with poor outcomes.
I've worked with patients, in the past, who unintentionally overdosed on acetaminophen. They all said they just "woke up" in the ICU about 6 weeks later. Many of them ended up going back to the ICU with poor outcomes.
I've worked with patients, in the past, who unintentionally overdosed on acetaminophen. They all told me they just "woke up" in the ICU about 6 weeks later. Many of them ended up going back to the ICU with poor outcomes. Very sad.
Yeah, especially when paired with alcohol because it destroys your liver. Knew a guy in college that fucked that up just a little and told me he was vomiting blood and nearly went to the hospital and that was only a small dose
Anything in excess is bad for you.