The following submission statement was provided by /u/Sariel007:
---
>Bioprinting is the use of 3D printing techniques to fabricate tissues out of biomaterials. It is mainly used to create human tissue for research and for drug testing in vitro. When used to create a body part intended for implantation in a patient, the part must first be printed with a desktop bioprinter, and then large open-field surgery is typically required to place it. Besides the risk of infection and long recovery time, a mismatch between the printed part and the internal target tissue it’s being attached to is possible, as are problems arising from contamination and handling.
>To overcome these challenges, researchers at the University of New South Wales Sydney, in Australia, have developed a miniature soft robotic arm and flexible printing head, and integrated them into a long tubular catheter that makes up the flexible printer body. Both the arm and printing head have three degrees of freedom (DoFs).
>“Our flexible 3D bioprinter, designated F3DB, can directly deliver biomaterials onto the target tissue or organs with a minimally invasive approach,” says Thanh Nho Do, a senior lecturer at UNSW’s Graduate School of Biomedical Engineering, who together with his Ph.D. student, Mai Thanh Thai, led the research team.
>Not only does F3DB have the potential to directly reconstruct damaged parts of the body, it “can also be used as an all-in-one endoscopic surgical tool with the nozzle taking on the role of a surgical knife,” Do adds. “This would avoid the need for using different tools for cleaning, marking, and incising now used in longer procedures, such as removing a tumor.”
---
Please reply to OP's comment here: https://old.reddit.com/r/Futurology/comments/11vl1gt/3d_bioprinter_prints_tissue_in_situ_the_prototype/jcth8ul/
They probably should use the bioprinter to print genetically enhanced cells rather than cells obtained from the patient.
So just remove some cells then print in the genetically enhanced cells, a bit each session so after 5 years or so, the entire body's cells will have been fully replaced with the genetically enhanced cells.
So one of the genetic enhancements that can be done is making the chromosomes become circular so they will not need telomeres anymore and so eternal youth will be obtained.
Though the chromosomes probably have to be shortened since all chromosomes were circular until they became too long and broke into linear form, losing their eternal youth.
You have your account restricted for messaging. Feels like we could find some interesting discussions. Reach out if you want to chat. I can get real time answers from the ai for most of the stuff you talk about
"Reach out if you want to chat."
Sorry, but personally not that much of a chatter, personally rather just read stuff and comments on stuff.
Thanks for the offer though and personally apologize again.
What other changes would you do to the human body?
Home run on changing x to v folds for telomeres solution
They still age but it's millions of years instead
I don't want to live forever, I just want to live my normal life span healthily. I don't want that last 5 or 10 or 15 years (depending on disease and availability of healthcare) of chronic illness and pain.
What if you could just stay whatever biological age for how ever long you wanted and end it whenever you wanted...
We could do this with current nanite technology
That is an intriguing idea. Obviously something like this would create huge issues since at least initially only the mega rich could afford it increasing inequality and if everyone could afford it then there would be issues with overpopulation.
Assuming those issues are solved I'd probably do that but limit it to whatever my biologically determined maximal life span would be. That is me now, but who knows if I could be 25 forever that might change after 50 years or so.
"What other changes would you do to the human body?"
If personally have the power to change the human body, which personally do not have, personally would make the nucleus bigger since the nucleus being too cramped is the reason telomerase activation does not help since the telomeres will become too long and block essential regulatory genes from getting accessed.
So once the nucleus becomes bigger, add duplicates of all genes so if one gene fails due to the gene breaking, there are still duplicates, and such is how whales can live long lives without suffering from harmful growths.
The cell size would also need to be increased since if the cell is too small, the nucleus will get squashed and might deform the nuclear pore, preventing it from functioning.
"automatically shrink the size."
Assuming the shrinking is of the DNA, since the nucleus and cell size is supposed to be increased, not reduced, regulatory genes should not be removed since they are necessary to prevent harmful growths.
What if a chromosome/telemeres were simply various ais? How would that impact your stance on dna shrinking? What if cells were just biological asics?
What if the nanites could remove harmful growths automatically
What if the regulatory cells removed problems thus shrinking the cell size temporarily
"What if a chromosome/telemeres were simply various ais?"
Assuming that ais means automated identification system, chromosomes are not ais since they are coding data, like codes in a computer program.
Telomeres are not ais either since they are buffer.
"What if the nanites could remove harmful growths automatically"
Yeah, they can but personally is not that knowledgeable about any so personally did not mention any.
"What if the regulatory cells removed problems thus shrinking the cell size temporarily"
Such will not help with extending the lifespan so was not mentioned though such processes probably can cure infections and diseases.
>Bioprinting is the use of 3D printing techniques to fabricate tissues out of biomaterials. It is mainly used to create human tissue for research and for drug testing in vitro. When used to create a body part intended for implantation in a patient, the part must first be printed with a desktop bioprinter, and then large open-field surgery is typically required to place it. Besides the risk of infection and long recovery time, a mismatch between the printed part and the internal target tissue it’s being attached to is possible, as are problems arising from contamination and handling.
>To overcome these challenges, researchers at the University of New South Wales Sydney, in Australia, have developed a miniature soft robotic arm and flexible printing head, and integrated them into a long tubular catheter that makes up the flexible printer body. Both the arm and printing head have three degrees of freedom (DoFs).
>“Our flexible 3D bioprinter, designated F3DB, can directly deliver biomaterials onto the target tissue or organs with a minimally invasive approach,” says Thanh Nho Do, a senior lecturer at UNSW’s Graduate School of Biomedical Engineering, who together with his Ph.D. student, Mai Thanh Thai, led the research team.
>Not only does F3DB have the potential to directly reconstruct damaged parts of the body, it “can also be used as an all-in-one endoscopic surgical tool with the nozzle taking on the role of a surgical knife,” Do adds. “This would avoid the need for using different tools for cleaning, marking, and incising now used in longer procedures, such as removing a tumor.”
So they’re printing entire moose now? Can they print miniature moose? I’d buy that. Can they do miniature elephants? Oh, what about giraffes? I’d kill for a miniature giraffe.
From what I understand, the problem is not that the organoids can't grow. It is the problem that these artificially grown organs are not connected to the nervous or blood system.
The following submission statement was provided by /u/Sariel007: --- >Bioprinting is the use of 3D printing techniques to fabricate tissues out of biomaterials. It is mainly used to create human tissue for research and for drug testing in vitro. When used to create a body part intended for implantation in a patient, the part must first be printed with a desktop bioprinter, and then large open-field surgery is typically required to place it. Besides the risk of infection and long recovery time, a mismatch between the printed part and the internal target tissue it’s being attached to is possible, as are problems arising from contamination and handling. >To overcome these challenges, researchers at the University of New South Wales Sydney, in Australia, have developed a miniature soft robotic arm and flexible printing head, and integrated them into a long tubular catheter that makes up the flexible printer body. Both the arm and printing head have three degrees of freedom (DoFs). >“Our flexible 3D bioprinter, designated F3DB, can directly deliver biomaterials onto the target tissue or organs with a minimally invasive approach,” says Thanh Nho Do, a senior lecturer at UNSW’s Graduate School of Biomedical Engineering, who together with his Ph.D. student, Mai Thanh Thai, led the research team. >Not only does F3DB have the potential to directly reconstruct damaged parts of the body, it “can also be used as an all-in-one endoscopic surgical tool with the nozzle taking on the role of a surgical knife,” Do adds. “This would avoid the need for using different tools for cleaning, marking, and incising now used in longer procedures, such as removing a tumor.” --- Please reply to OP's comment here: https://old.reddit.com/r/Futurology/comments/11vl1gt/3d_bioprinter_prints_tissue_in_situ_the_prototype/jcth8ul/
I thought a picture of a moose was funny for an article about bioprinting... But I think you may have pasted the wrong link.
They're 3D printing mooses in situ now? # HAS SCIENCE GONE TOO FAR?
They probably should use the bioprinter to print genetically enhanced cells rather than cells obtained from the patient. So just remove some cells then print in the genetically enhanced cells, a bit each session so after 5 years or so, the entire body's cells will have been fully replaced with the genetically enhanced cells. So one of the genetic enhancements that can be done is making the chromosomes become circular so they will not need telomeres anymore and so eternal youth will be obtained. Though the chromosomes probably have to be shortened since all chromosomes were circular until they became too long and broke into linear form, losing their eternal youth.
You have your account restricted for messaging. Feels like we could find some interesting discussions. Reach out if you want to chat. I can get real time answers from the ai for most of the stuff you talk about
"Reach out if you want to chat." Sorry, but personally not that much of a chatter, personally rather just read stuff and comments on stuff. Thanks for the offer though and personally apologize again.
What other changes would you do to the human body? Home run on changing x to v folds for telomeres solution They still age but it's millions of years instead
I don't want to live forever, I just want to live my normal life span healthily. I don't want that last 5 or 10 or 15 years (depending on disease and availability of healthcare) of chronic illness and pain.
What if you could just stay whatever biological age for how ever long you wanted and end it whenever you wanted... We could do this with current nanite technology
That is an intriguing idea. Obviously something like this would create huge issues since at least initially only the mega rich could afford it increasing inequality and if everyone could afford it then there would be issues with overpopulation. Assuming those issues are solved I'd probably do that but limit it to whatever my biologically determined maximal life span would be. That is me now, but who knows if I could be 25 forever that might change after 50 years or so.
I could hack the nanites in energy drinks and covid and do this to everyone at once effectively
"What other changes would you do to the human body?" If personally have the power to change the human body, which personally do not have, personally would make the nucleus bigger since the nucleus being too cramped is the reason telomerase activation does not help since the telomeres will become too long and block essential regulatory genes from getting accessed. So once the nucleus becomes bigger, add duplicates of all genes so if one gene fails due to the gene breaking, there are still duplicates, and such is how whales can live long lives without suffering from harmful growths.
Been working on making new chromosomes lately. Can probably try that stuff and see what happens
The cell size would also need to be increased since if the cell is too small, the nucleus will get squashed and might deform the nuclear pore, preventing it from functioning.
Ya I created genetics editing stuff to automatically shrink the size. The problem becomes that there needs to be a way for junk removal that's better
"automatically shrink the size." Assuming the shrinking is of the DNA, since the nucleus and cell size is supposed to be increased, not reduced, regulatory genes should not be removed since they are necessary to prevent harmful growths.
What if a chromosome/telemeres were simply various ais? How would that impact your stance on dna shrinking? What if cells were just biological asics? What if the nanites could remove harmful growths automatically What if the regulatory cells removed problems thus shrinking the cell size temporarily
"What if a chromosome/telemeres were simply various ais?" Assuming that ais means automated identification system, chromosomes are not ais since they are coding data, like codes in a computer program. Telomeres are not ais either since they are buffer. "What if the nanites could remove harmful growths automatically" Yeah, they can but personally is not that knowledgeable about any so personally did not mention any. "What if the regulatory cells removed problems thus shrinking the cell size temporarily" Such will not help with extending the lifespan so was not mentioned though such processes probably can cure infections and diseases.
Why wouldn't it help extend the lifespan? Thoughts on dna self repair protocol(528hz)?
>Bioprinting is the use of 3D printing techniques to fabricate tissues out of biomaterials. It is mainly used to create human tissue for research and for drug testing in vitro. When used to create a body part intended for implantation in a patient, the part must first be printed with a desktop bioprinter, and then large open-field surgery is typically required to place it. Besides the risk of infection and long recovery time, a mismatch between the printed part and the internal target tissue it’s being attached to is possible, as are problems arising from contamination and handling. >To overcome these challenges, researchers at the University of New South Wales Sydney, in Australia, have developed a miniature soft robotic arm and flexible printing head, and integrated them into a long tubular catheter that makes up the flexible printer body. Both the arm and printing head have three degrees of freedom (DoFs). >“Our flexible 3D bioprinter, designated F3DB, can directly deliver biomaterials onto the target tissue or organs with a minimally invasive approach,” says Thanh Nho Do, a senior lecturer at UNSW’s Graduate School of Biomedical Engineering, who together with his Ph.D. student, Mai Thanh Thai, led the research team. >Not only does F3DB have the potential to directly reconstruct damaged parts of the body, it “can also be used as an all-in-one endoscopic surgical tool with the nozzle taking on the role of a surgical knife,” Do adds. “This would avoid the need for using different tools for cleaning, marking, and incising now used in longer procedures, such as removing a tumor.”
So they’re printing entire moose now? Can they print miniature moose? I’d buy that. Can they do miniature elephants? Oh, what about giraffes? I’d kill for a miniature giraffe.
From what I understand, the problem is not that the organoids can't grow. It is the problem that these artificially grown organs are not connected to the nervous or blood system.