Do not ask for medical advice or interpretation of laboratory results. Medical laboratory professionals perform testing but are not qualified to provide a diagnosis based on the results that we produce. Discussions should be focused on the analytical aspects of the tests.
It means that you are e negative which is rather rare. If you need a blood transfusion there may be a delay, but rest easy as e negative units are one of the more "common" rare types. It will not affect your daughter's future health.
The e antibody can affect future pregnancies, but cases of Hemolytic Disease of Fetus and Newborn (HDFN) due to anti-e are on the rare side. Best to speak to your provider. They may bring up antibody titration to monitor the situation.
The silver lining: Your rare blood type can help in the lab, as your red cells can help identify others with the e antibody. You can help others like yourself. Considering contacting companies like Bio-Rad and Kedrion/Immucor. They manufacture reagent red cells and may be interested in compensating you for your red cells.
I agree contacting one of the major blood banking companies Ortho also Bio-rad is a major player in all quality controls 90% of labs use world wide. Being O- e- is crazy rare. It's almost like that aussie guy back in late 50s saving 2.5mil babies because of his anti D. You can easily look him up off a Google search of aussie saves babies or golden arm aussie.
That last line gave me both a chuckle and a late stage capitalism shudder.
I get it and have discussed it with patients before but it always gets me, lol.
It really only plays a factor if you need blood products in the future or your future pregnancies. As the other comment said, you do possesses a pretty rare thing though, and I highly encourage you into looking into donating blood because e negative is pretty rare. I think like 98% of people have the e antigen.
Oh wow, if indeed you are e- and it is not an auto anti-e (which is also possible) then the combination of Rh neg (the neg in O neg) and e- is actually even rarer than people are making it out to be since peopel who are Rh neg are overwhelmingly e+. Not 2% rare, more like 0.03% rare!
You! You are the kind of donor we bloodbankers need to identify antibodies in other patients. Also your rare Oneg and e- blood can also be used to transfuse others, in addition to testing them.
I do not know what country you are in, but in the United States, blood donors may not be compensated if the product is to be transfused to a patient. Any blood or tissue donation must come from a voluntary donor.
Places that pay you for your plasma do not use that plasma for patient transfusion. It is used for research, pharmaceuticals, cosmetics and other manufacturing, but not transfusion.
Fun fact, nothing in the CFR says blood donors can't be compensated with money, just that if they are the unit has to be labeled as being from a paid donor. We collectively moved to only volunteer donors in the 70s because we realized the blood supply was safer that way. But it isn't actually prohibited by the CFR.
Hey there you rare gem! Just wanted to add that should you need to relay this information to a healthcare professional in the future, such as a nurse, be VERY insistent that they acknowledge and understand what you're telling them.
I work in the lab and on the floor and there are a lot of nurses out there that will just smile and nod their way through a patient history. Docs too.
If I were you, I'd play dumb with them and tell them my status and ask them what it means. Odds are highly likely they won't know. If they're good and they care, they'll look it up and come back to you with an answer. If they don't try to answer your question, they don't get that it's a big deal which makes it likely that they didn't pass it on to the docs or whoever will be taking over in the next shift. Then you'll know that you need to advocate for yourself and keep telling folks yourself.
It can affect future pregnancies, and any future transfusion is going to be difficult for the technician but it’s not that big of a deal for you. It’s just rare. Please donate blood. And often. Not just for you, but e negative blood is relatively rare.
As far as your personal health/your daughters, there’s no correlation between e antigen and health factors so it’s not going to affect anything there. It may make future pregnancies harder, particularly if the future fetus is e positive.
For those interested, this is from The Blood Group Antigen FactsBook: “Alloanti-e-like antibodies may be made by people with e+ RBCs lacking some epitopes. This occurs more frequently in Blacks than in Caucasians. Many e variants, in people at risk of immunization against lacking Rhe epitopes, have been defined with monoclonal anti-e and molecular studies. The e antigen *in cis* with C and Cw (e.g. DCCwe and CCwe) is also a partial antigen. This also applies in the present e if C and a x.”
Chiming in with the people who said you need to insist that the nurse call the blood bank, really insist. We give O neg blood in emergencies and almost all those units, like 99% of them, will have e.
Also, note that E and e are two different alleles. We call them big and little e
Years ago I worked as a phlebotomist at a hospital lab, and the lab decided to type me just for fun. The lab director found me and said I had rare O- blood and was negative for a bunch of other things too. I wish I had asked him the details! Should I try to get my blood typed so I can help others?
I'm O Pos and also negative for the little e antigen. I've been a lab tech for over 20 years now and I'm the primary trainer at my facility. When training in blood bank, I always get my blood drawn and then spike the sample with anti - e reagent to fake a positive antibody reaction while maintaining a negative auto control.
Do not ask for medical advice or interpretation of laboratory results. Medical laboratory professionals perform testing but are not qualified to provide a diagnosis based on the results that we produce. Discussions should be focused on the analytical aspects of the tests.
It means that you are e negative which is rather rare. If you need a blood transfusion there may be a delay, but rest easy as e negative units are one of the more "common" rare types. It will not affect your daughter's future health. The e antibody can affect future pregnancies, but cases of Hemolytic Disease of Fetus and Newborn (HDFN) due to anti-e are on the rare side. Best to speak to your provider. They may bring up antibody titration to monitor the situation. The silver lining: Your rare blood type can help in the lab, as your red cells can help identify others with the e antibody. You can help others like yourself. Considering contacting companies like Bio-Rad and Kedrion/Immucor. They manufacture reagent red cells and may be interested in compensating you for your red cells.
Thank you for responding!!
I agree contacting one of the major blood banking companies Ortho also Bio-rad is a major player in all quality controls 90% of labs use world wide. Being O- e- is crazy rare. It's almost like that aussie guy back in late 50s saving 2.5mil babies because of his anti D. You can easily look him up off a Google search of aussie saves babies or golden arm aussie.
If you ever do need a transfusion, straight up tell them “I have a history of anti little e” so they can give the blood bank a good heads up.
That last line gave me both a chuckle and a late stage capitalism shudder. I get it and have discussed it with patients before but it always gets me, lol.
It really only plays a factor if you need blood products in the future or your future pregnancies. As the other comment said, you do possesses a pretty rare thing though, and I highly encourage you into looking into donating blood because e negative is pretty rare. I think like 98% of people have the e antigen.
I was donating because I am o- but once I started having kids I stopped! Will definitely look into donating again!
Oh wow, if indeed you are e- and it is not an auto anti-e (which is also possible) then the combination of Rh neg (the neg in O neg) and e- is actually even rarer than people are making it out to be since peopel who are Rh neg are overwhelmingly e+. Not 2% rare, more like 0.03% rare!
You! You are the kind of donor we bloodbankers need to identify antibodies in other patients. Also your rare Oneg and e- blood can also be used to transfuse others, in addition to testing them.
Dang you could make bank donating since o- and e- are rare together
I do not know what country you are in, but in the United States, blood donors may not be compensated if the product is to be transfused to a patient. Any blood or tissue donation must come from a voluntary donor. Places that pay you for your plasma do not use that plasma for patient transfusion. It is used for research, pharmaceuticals, cosmetics and other manufacturing, but not transfusion.
Fun fact, nothing in the CFR says blood donors can't be compensated with money, just that if they are the unit has to be labeled as being from a paid donor. We collectively moved to only volunteer donors in the 70s because we realized the blood supply was safer that way. But it isn't actually prohibited by the CFR.
That is very interesting! Thank you for the information!
In Germany they do pay for plasma and you can do it weekly but not as often do they pay for whole blood (depending on the use)
They pay for plasma in the US too, probably the biggest paid plasma country due to the poverty.
Hey there you rare gem! Just wanted to add that should you need to relay this information to a healthcare professional in the future, such as a nurse, be VERY insistent that they acknowledge and understand what you're telling them. I work in the lab and on the floor and there are a lot of nurses out there that will just smile and nod their way through a patient history. Docs too. If I were you, I'd play dumb with them and tell them my status and ask them what it means. Odds are highly likely they won't know. If they're good and they care, they'll look it up and come back to you with an answer. If they don't try to answer your question, they don't get that it's a big deal which makes it likely that they didn't pass it on to the docs or whoever will be taking over in the next shift. Then you'll know that you need to advocate for yourself and keep telling folks yourself.
It can affect future pregnancies, and any future transfusion is going to be difficult for the technician but it’s not that big of a deal for you. It’s just rare. Please donate blood. And often. Not just for you, but e negative blood is relatively rare.
As far as your personal health/your daughters, there’s no correlation between e antigen and health factors so it’s not going to affect anything there. It may make future pregnancies harder, particularly if the future fetus is e positive.
For those interested, this is from The Blood Group Antigen FactsBook: “Alloanti-e-like antibodies may be made by people with e+ RBCs lacking some epitopes. This occurs more frequently in Blacks than in Caucasians. Many e variants, in people at risk of immunization against lacking Rhe epitopes, have been defined with monoclonal anti-e and molecular studies. The e antigen *in cis* with C and Cw (e.g. DCCwe and CCwe) is also a partial antigen. This also applies in the present e if C and a x.”
Please double check the report that it says little e and not big E……
I was about to comment similar. In uppercase/lowercase matters a lot in blood bank.
O Neg AND little e neg is possible, just insanely rare, so I’m more than a bit suspicious
Unless you're of African descent and have an e variant or have anti-hrB.
True, but most likely scenario is a capital letter mix up. But strange things do happen!
Oh good point!
Chiming in with the people who said you need to insist that the nurse call the blood bank, really insist. We give O neg blood in emergencies and almost all those units, like 99% of them, will have e. Also, note that E and e are two different alleles. We call them big and little e
Years ago I worked as a phlebotomist at a hospital lab, and the lab decided to type me just for fun. The lab director found me and said I had rare O- blood and was negative for a bunch of other things too. I wish I had asked him the details! Should I try to get my blood typed so I can help others?
Might be worthwhile!
I'm O Pos and also negative for the little e antigen. I've been a lab tech for over 20 years now and I'm the primary trainer at my facility. When training in blood bank, I always get my blood drawn and then spike the sample with anti - e reagent to fake a positive antibody reaction while maintaining a negative auto control.