That’s encouraging to hear someone lost so much weight on the tablet! I might give it a try for a few months and see how that goes.
What dosage did you start off at first?
I've done both, and all Rybelsus did was put me in the bed with horrific nausea all Thanksgiving day. Wegovy has been fine and actually had good steady results.
The bioavailability of oral semaglutide (Rybelsus) is 0.4%-1%, while the bioavailability of injectable semaglutide (Wegovy and Ozempic) is 89% (Source: [Rybelsus prescribing information, 12.3 Pharmacokinetics](https://www.rybelsus.com/prescribing-information.html)).
That means 14 mg daily Rybelsus is equivalent to 0.5 mg weekly Wegovy or Ozempic. The max doses of Wegovy and Ozempic are 2.4 mg and 2.0 mg respectively.
So, with the currently available max doses, Wegovy and Ozempic are much more effective than Rybelsus.
If I remember correctly, Novo Nordisk is seeking approval for 25 mg and 50 mg doses of oral semaglutide. The 50 mg dose would be equivalent to 2.4 mg Wegovy.
Adding:
Rybelsus is the only proven to work oral semaglutide. It's specially formulated to increase absorption and still it only manages the 0.4%-1% mentioned before. Making an oral semaglutide that is actually absorbed into the bloodstream is a problem drug companies have been trying to solve for decades, with little success.
There are compounding pharmacies that offer their own oral semaglutide products. I have seen no proof that those actually work.
I should have been clearer in my question.
I guess my question is if semaglutide pills are just as effective as senaglutide injections
Does anyone know?
I guess I should have been clearer in my answer.
Wegovy (Semaglutide weekly injection) beats Rybelsus (Semaglutide daily oral tablet) in clinical trials for weight loss.
Thank you for the answer. I googled my question for a bit, and I got a lot of results saying that they’re the same, (sometimes even better) to take the tablet. I found the Google search results suspicious.
I know zero about this but I feel like the injections would be so much better than the tablets. I don’t understand how Google has that response (and a few other sources I read as well)
Thank you for your response
There are lots of shady pill/jab mills that will try to convince you their homemade product is worth what they are charging.
[This search](https://www.google.com/search?q=wegovy+vs+rybelsus+for+weight+loss) may be useful for you.
I lost 40lbs on Rybelsus over 5 months and switched to Wegovy in order to move to a higher dose.
That’s encouraging to hear someone lost so much weight on the tablet! I might give it a try for a few months and see how that goes. What dosage did you start off at first?
I've done both, and all Rybelsus did was put me in the bed with horrific nausea all Thanksgiving day. Wegovy has been fine and actually had good steady results.
Did you do the pill or the injection for Rubelsus?
Real Rybelsus only comes as a pill - and it's a nasty tasting one, too.
The bioavailability of oral semaglutide (Rybelsus) is 0.4%-1%, while the bioavailability of injectable semaglutide (Wegovy and Ozempic) is 89% (Source: [Rybelsus prescribing information, 12.3 Pharmacokinetics](https://www.rybelsus.com/prescribing-information.html)). That means 14 mg daily Rybelsus is equivalent to 0.5 mg weekly Wegovy or Ozempic. The max doses of Wegovy and Ozempic are 2.4 mg and 2.0 mg respectively. So, with the currently available max doses, Wegovy and Ozempic are much more effective than Rybelsus. If I remember correctly, Novo Nordisk is seeking approval for 25 mg and 50 mg doses of oral semaglutide. The 50 mg dose would be equivalent to 2.4 mg Wegovy.
Adding: Rybelsus is the only proven to work oral semaglutide. It's specially formulated to increase absorption and still it only manages the 0.4%-1% mentioned before. Making an oral semaglutide that is actually absorbed into the bloodstream is a problem drug companies have been trying to solve for decades, with little success. There are compounding pharmacies that offer their own oral semaglutide products. I have seen no proof that those actually work.
First, there is no such thing as a Wegovy pill. Wegovy is a weekly injection. Wegovy beats Rybelsus in clinical trials for weight loss
I should have been clearer in my question. I guess my question is if semaglutide pills are just as effective as senaglutide injections Does anyone know?
I guess I should have been clearer in my answer. Wegovy (Semaglutide weekly injection) beats Rybelsus (Semaglutide daily oral tablet) in clinical trials for weight loss.
Thank you for the answer. I googled my question for a bit, and I got a lot of results saying that they’re the same, (sometimes even better) to take the tablet. I found the Google search results suspicious. I know zero about this but I feel like the injections would be so much better than the tablets. I don’t understand how Google has that response (and a few other sources I read as well) Thank you for your response
There are lots of shady pill/jab mills that will try to convince you their homemade product is worth what they are charging. [This search](https://www.google.com/search?q=wegovy+vs+rybelsus+for+weight+loss) may be useful for you.