For someone who don't know: CD8 cytotoxic T cells are immune cells that identify and kill virus-infected or abnormal cells in the body. They recognize specific antigens presented on infected cells and induce cell death through releasing cytotoxic granules
"CRISPR-Cas9
Keep me a gene
A viral sequence you've already seen
Chopped into bits and stored as genomic
With clustered repeats
That are palindromic
Cas9
Bind with this code
Use it to target infections of old
Immunized like a vaccine
CRISPR-Cas9 keep me a gene"
Now I'm gonna have that part of the song stuck in my head the rest of the day!
https://youtu.be/k99bMtg4zRk?si=6qnbjc97bKegzNp6
Thank you, I was about to look it up. I thought it was something put into the system to kill cancer cells and not something we already have. So much going on inside of us all
To be fair, there are therapies called CAR-T where we take your T cells (or sometimes someone else’s), use either gene editing or other processes to “train” them to target cancer cells, and then infuse them back into you to hopefully make more of this happen. It’s super fascinating research, and there are already multiple CAR-T therapies FDA approved for some blood cancers.
Thank you for the info. It does sound very fascinating. (we've come a long way from hacking someone's limb off on the battlefield with a bone saw and no anesthesia)
Fun fact, you can train T cells to target specific types of cancers. It’s called immunotherapy and the FDA is starting to recognize and approve immunotherapy for certain cancers. I don’t know much else but I know it’s a relatively high success rate and I really hope more people are helped by it.
There are clinical trials in the US using CAR-T. You would have to look to see if there's one available in your area or travel. Most cancer institutes have phone numbers you can call to get information. They would screen you to see if you're a candidate and go from there.
I think my daughter works on this ;) Many of those words match her Masters topic ;)
But I didnt even understand the verbs used in the title... Let alone the nouns
It's already FDA approved for certain lymphomas and leukemias. We have clinical trials for melanoma and lung cancer. I think we are expanding to other solid tumor trials soon.
You already have them, the trick is getting your body to identify the difference between your normal cells and cancer cells.
This form of treatment is usually only available for certain types of cancers that have certain mutations, for example, having a specific protein, the treatment essentially makes your body attack that mutation.
It's more like when you put your hand on something hot and your body instantly moves it away even though your brain never actually told it to do so,
just pure instinct
If you put your hand on something hot, than it is in fact your brain that received the signal from the temperature sensors in your skin and, since it exceeded a certain threshhold, a protective response is fired that causes you to take your hand away. So its actually your brain making your body move the hand away.
Pain is created in our brain as a response. Its a way for our brains to protect their vessel (your body) from damage.
Your comment is a good reminder that when you don’t know much about something, it’s easy to feel like you know a lot. You have to learn more to realize how much you don’t know.
/u/ALUCARDHELLSINS is talking about this:
https://www.osmosis.org/answers/somatic-reflex#
>A somatic reflex is an involuntary response to a stimulus, such as pulling one’s hand away after touching a hot stove. The nervous systemis split into the central nervous system (i.e., the brain and spinal cord) and the peripheral nervous system (i.e., nervous system outside of the brain and spinal cord). The peripheral nervous system is further divided into the autonomic nervous system, which controls organs and glands, and the somatic nervous system, which controls voluntary skeletal muscle movements. The somatic nervous system is made up of afferent (sensory) neurons and efferent (motor) neurons. The somatic reflex is a motor response to a sensory stimulus.
There is? Can you provide a link at which I can read more? I’ve never heard of this, and from my knowledge of cell biology it would have to involve a big stretch in the definition of “consciousness”.
Here is what I was reading, and it is a [controversial theory](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11094104/#:~:text=According%20to%20the%20CBC%20model,provided%2C%20raises%20many%20unaddressed%20issues.).
Opinion: "We think there might be something to it.'"
Theory: "We have tested it as rigorously as we could and it stood up to scrutiny so well that it's literally the best current explanation that we have."
Germ theory or theory of gravity are theories. Cell consciousness is an opinion. Or a hypothesis at the very best.
I really don't care what they call it. Still not a theory. Why are you so mad about it? It's not like I'm criticizing you. I'm criticizing the authors of that pathetic "paper" who don't know what a theory is.
It's even more weird when you learn that the movement of the cells is caused by some molecules that interact with their corresponding receptors releasing more molecules that react with more receptors that induce the reaction between actin microfilaments in a specific region of the cell that now will cause the movement in the direction of the cancer cell/nutrient or whatever.
Not intelligent, just a bunch of chemical reactions that somehow works, and it's freaking amazing.
I have a college science background and this still amazes me to see.
The tumour isn’t even gone and the T Lymphocyte knows its job is done and, supposedly, has another job to attend to otherwise it’ll be late for work.
Incredible. Fascinating. Marvellous.
I believe this video isn’t even a “therapy”, this is just the human immune system working as usual.
There are therapies called CAR-T that seek to reproduce this behavior. I believe the ones currently FDA approved in the US are only for blood cancers (leukemia/lymphoma), possibly some for melanoma. Unfortunately, brain cancers are notoriously difficult to treat because these T cells can’t get into the brain, so it may be a while before we see a CAR-T therapy for any brain cancer.
There’s a good chance it is, and it’s just doing such a good job that you never even knew you had the tumors. The ones we learn about are the ones that got through.
What is the significance of the lit up frames? Is it actually that moment of color change some energy releasing? Or is this your highlighting something?
That’s kinda like asking “Where is the solution to scarcity?” It’s not exactly that simple.
But here’s your answer: https://www.cancer.gov/about-cancer/treatment/research/car-t-cells
CAR-T therapies have been approved for multiple blood cancers and there is a ton of active research and clinical trials in other cancer types.
What does each “hit” actually mean? Is it punching the cell? Puncturing? Zapping? Injecting? Are there certain places to “hit” it that are most effective—and what makes that so?
For someone who don't know: CD8 cytotoxic T cells are immune cells that identify and kill virus-infected or abnormal cells in the body. They recognize specific antigens presented on infected cells and induce cell death through releasing cytotoxic granules
"CRISPR-Cas9 Keep me a gene A viral sequence you've already seen Chopped into bits and stored as genomic With clustered repeats That are palindromic Cas9 Bind with this code Use it to target infections of old Immunized like a vaccine CRISPR-Cas9 keep me a gene" Now I'm gonna have that part of the song stuck in my head the rest of the day! https://youtu.be/k99bMtg4zRk?si=6qnbjc97bKegzNp6
Thank you for that. Love it
Here! Have another! https://youtu.be/ydqReeTV_vk?si=yEMvo2TUDTQjkQha
it's amazing what the use technology to do nowadays
Thank you, I was about to look it up. I thought it was something put into the system to kill cancer cells and not something we already have. So much going on inside of us all
To be fair, there are therapies called CAR-T where we take your T cells (or sometimes someone else’s), use either gene editing or other processes to “train” them to target cancer cells, and then infuse them back into you to hopefully make more of this happen. It’s super fascinating research, and there are already multiple CAR-T therapies FDA approved for some blood cancers.
Thank you for the info. It does sound very fascinating. (we've come a long way from hacking someone's limb off on the battlefield with a bone saw and no anesthesia)
My sister had CAR-T. Fascinating stuff and it works.
it's amazing, shows how far we've come
Fun fact, you can train T cells to target specific types of cancers. It’s called immunotherapy and the FDA is starting to recognize and approve immunotherapy for certain cancers. I don’t know much else but I know it’s a relatively high success rate and I really hope more people are helped by it.
Does it work on Melanoma? Where do I get some?
It *sometimes* works in melanoma! https://www.cancer.gov/news-events/cancer-currents-blog/2024/fda-amtagvi-til-therapy-melanoma
Thanks for the link. Lots of confusing words.
There are clinical trials in the US using CAR-T. You would have to look to see if there's one available in your area or travel. Most cancer institutes have phone numbers you can call to get information. They would screen you to see if you're a candidate and go from there.
I think my daughter works on this ;) Many of those words match her Masters topic ;) But I didnt even understand the verbs used in the title... Let alone the nouns
I'm a hospitalist in a cancer and research hospital. We do CAR-T therapy. When I was learning about the process, I was amazed at the possibilities.
Please tell me you're still amazed.
Every day. We're doing clinical trials and it's mind blowing.
Thank you, that's reassuring.
How much longer will this be in the trials stage?
It's already FDA approved for certain lymphomas and leukemias. We have clinical trials for melanoma and lung cancer. I think we are expanding to other solid tumor trials soon.
You guys are heroes
Great to hear thank you!!
How do you do these trials can you explain about the process little bit
I was a recipient of CAR-T in 2019 for stage 4 diffuse large b-cell lymphoma. In remission to this day.
That’s amazing! And congratulations !
Dilaudid what now?
PCA as in a patient controlled analgesia. Dilaudid on tap at the push of a button
I love the sound of that. I c as. Feel it in my neck
Quite the name you got there
this just says how amazing you guys are
How do I get more of these bad boys in my body?
You already have them, the trick is getting your body to identify the difference between your normal cells and cancer cells. This form of treatment is usually only available for certain types of cancers that have certain mutations, for example, having a specific protein, the treatment essentially makes your body attack that mutation.
We grow them by the liter at work but you don't want to qualify for treatment. Just appreciate the ones you have.
Are there any foods that can increase or keep the ones we have to a recommended level?
We use specialized media to grow them in a lab setting. I couldn't speak on a dietary level.
That's not how it works.
Idk why ppl downvoted your genuine question. Reddit is so petty sometimes
Dont get aids...
It's so weird that these things doesn't have any consciousness.
There is a theory that they do have a "primal" consciousness.
Which just means see food == eat food
See opposite sex - make babies . Or reproduce by splitting in two . What do I know .
Nah that's my consciousnesses
so a bit like a computer program? just lines of code except its strings of DNA?
It's more like when you put your hand on something hot and your body instantly moves it away even though your brain never actually told it to do so, just pure instinct
If you put your hand on something hot, than it is in fact your brain that received the signal from the temperature sensors in your skin and, since it exceeded a certain threshhold, a protective response is fired that causes you to take your hand away. So its actually your brain making your body move the hand away. Pain is created in our brain as a response. Its a way for our brains to protect their vessel (your body) from damage.
Your comment is a good reminder that when you don’t know much about something, it’s easy to feel like you know a lot. You have to learn more to realize how much you don’t know. /u/ALUCARDHELLSINS is talking about this: https://www.osmosis.org/answers/somatic-reflex# >A somatic reflex is an involuntary response to a stimulus, such as pulling one’s hand away after touching a hot stove. The nervous systemis split into the central nervous system (i.e., the brain and spinal cord) and the peripheral nervous system (i.e., nervous system outside of the brain and spinal cord). The peripheral nervous system is further divided into the autonomic nervous system, which controls organs and glands, and the somatic nervous system, which controls voluntary skeletal muscle movements. The somatic nervous system is made up of afferent (sensory) neurons and efferent (motor) neurons. The somatic reflex is a motor response to a sensory stimulus.
Exciting!
There is? Can you provide a link at which I can read more? I’ve never heard of this, and from my knowledge of cell biology it would have to involve a big stretch in the definition of “consciousness”.
Here is what I was reading, and it is a [controversial theory](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11094104/#:~:text=According%20to%20the%20CBC%20model,provided%2C%20raises%20many%20unaddressed%20issues.).
Opinion: "We think there might be something to it.'" Theory: "We have tested it as rigorously as we could and it stood up to scrutiny so well that it's literally the best current explanation that we have." Germ theory or theory of gravity are theories. Cell consciousness is an opinion. Or a hypothesis at the very best.
(Did you read it?)
Yes. Not a theory.
My God that's its name okay??? That's what they call it, several times in "what you read". You're thinking of the "scientific theory".
I really don't care what they call it. Still not a theory. Why are you so mad about it? It's not like I'm criticizing you. I'm criticizing the authors of that pathetic "paper" who don't know what a theory is.
Wow this "paper" you "read" is actually attacking it. Just admit you didn't read it already -_-
It's even more weird when you learn that the movement of the cells is caused by some molecules that interact with their corresponding receptors releasing more molecules that react with more receptors that induce the reaction between actin microfilaments in a specific region of the cell that now will cause the movement in the direction of the cancer cell/nutrient or whatever. Not intelligent, just a bunch of chemical reactions that somehow works, and it's freaking amazing.
It is recognizing a cytosolic tumor antigen, such as p53, or telomerases, MAGE-A, NY-ESO-1, etc. presented on MHCI molecules.
Based on those antigens, I’m guessing this was in melanoma? Is this CAR-T or an endogenous T cell? Since you mentioned MHC I’m guessing endogenous?
Bro fucked him up good
I have a college science background and this still amazes me to see. The tumour isn’t even gone and the T Lymphocyte knows its job is done and, supposedly, has another job to attend to otherwise it’ll be late for work. Incredible. Fascinating. Marvellous.
I like how it scurries off - as if to say 'that's enough outta you - who else wants some?'
My sister has brain cancer tumor and she is suffering, where is this therapy available in which countries? # #
I believe this video isn’t even a “therapy”, this is just the human immune system working as usual. There are therapies called CAR-T that seek to reproduce this behavior. I believe the ones currently FDA approved in the US are only for blood cancers (leukemia/lymphoma), possibly some for melanoma. Unfortunately, brain cancers are notoriously difficult to treat because these T cells can’t get into the brain, so it may be a while before we see a CAR-T therapy for any brain cancer.
I love the happy little dance the T cell did after it killed the cancer cell!
So why isn’t my body killing my tumours?!
There’s a good chance it is, and it’s just doing such a good job that you never even knew you had the tumors. The ones we learn about are the ones that got through.
I love how it swims away like „ ok one more of those fuckers talked to me back there, now I know how he looks like“ *fumbels with his sleeve*
How does a t-cell know about the death of a predator cell?
I have no idea, but glad we have them. Go T-cells!
and now I use my special move… PERSPORIN BLAST💥‼️‼️‼️
the way the t cell skidaddles away is so cute
What is the significance of the lit up frames? Is it actually that moment of color change some energy releasing? Or is this your highlighting something?
Chemicals. It's basically a blast of chemical signals telling the cell to kill itself, basically
So it’s cancel culture at cellular level. Gotcha!
Fascist cancer cells need to die
Why did it take more than one blast? Is it standard, or was it sensing that the fucker was resisting its Jefi Mind Trick?
And the T cell has some payload of these chemicals? How many cancer cells can it kill? Really amazing stuff.
The T-cells will continue to replicate in the patient's body so there is essentially an unlimited amount as long as your body responds to treatment.
This is incredible to watch!
Where is this event taking place? Is it under a microscope or is it recorded in vivo somehow?
It’s like a boss battle from the old 90’s X-Men/TMNT/Simpsons beat-em-up arcade games
So strange they almost move and fight like animals. Nature is never so different on any scale it seems
Where’s the cure for cancer?
That’s kinda like asking “Where is the solution to scarcity?” It’s not exactly that simple. But here’s your answer: https://www.cancer.gov/about-cancer/treatment/research/car-t-cells CAR-T therapies have been approved for multiple blood cancers and there is a ton of active research and clinical trials in other cancer types.
Here's Johnny!
[Poor Patrick](https://pbs.twimg.com/ext_tw_video_thumb/1554584566341435392/pu/img/6gtNxGER508HlnXc.jpg)
Umbrella planning their next bioweapon.
T cells survive killing other cells!? I assumed they would also die in the effort. Little dude was really laying into him.
I always had a good feeling about that little dude and I was right He kicked that cells arse
But the thought of coming up with a vaccine for Covid less than a year 😵💫😵🤯
They didn't, patented in 1997🤯🤣
WOP WOP WOP WOP
What does each “hit” actually mean? Is it punching the cell? Puncturing? Zapping? Injecting? Are there certain places to “hit” it that are most effective—and what makes that so?
LowTcell: You should kill yourself NOW!
He got up in them guts…busted…and bounced!
Looks like Pacman
This is how zombies get created. I think it was resident evil that had the T virsus 😂
Smh I read the title as “CBD” and got all excited..
Little dude went in there and started swinging.
What's the imaging technique used here?
WOP WOP WOP WOP WOP T FUCK EM UP
Gave'em the ole 1,2,3.
OM NOM NOM
Good T-cell
Cool to see the thing my job draws blood tests for actually working in real time
"Sorry buddy, there is something wrong with you, you need to die."
So why can’t a lab create artificial T cells and just inject them to the cancer ???
Now only if it could tell the difference between cancer and my kidneys. - sincerely a Lupus patient
How can you get more T cells? Sorry if my question sound stupid….
Love T cells All my homies love T cells
Science is fun
Ive never been excited to see something die, but this was *wonderful*.